S100B的研究进展

被引：12

作者：

云永利

陈萍

机构：

[1] 内蒙古自治区人民医院神经内科

来源：

医学综述 | 2017年 / 23卷 / 01期

关键词：

脑损伤; S100B; 细胞治疗;

D O I：

暂无

中图分类号：

R3411 [];

学科分类号：

1001 ;

摘要：

S100B是一种钙离子结合蛋白,在脑中主要由神经胶质细胞分泌,外周的成肌细胞也可分泌。S100B的作用与其浓度有关,生理浓度的S100B具有神经营养作用,可促进神经元轴突生长,抑制神经元凋亡,促进神经胶质细胞增生;而过多的S100B通过与其配体糖基化终产物受体结合,促进神经元、神经胶质细胞凋亡,并且促进神经胶质细胞参与并放大炎症反应,参与脑损伤过程。另外,在外周,S100B可促进成肌细胞的增殖,为临床肌营养不良的细胞治疗奠定了理论基础。

引用

页码：46 / 49

页数：4

共 16 条

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