血浆同型半胱氨酸水平与腹主动脉瘤的相关性研究

被引：5

作者：

刘杰

贾鑫

贾森皓

徐清华

葛阳阳

吴忠隐

郭伟

机构：

[1] 解放军总医院血管外科

来源：

中华老年心脑血管病杂志 | 2014年 / 16卷 / 05期

关键词：

高半胱氨酸; 主动脉瘤,腹; 高同种半胱氨酸血症; 危险因素;

D O I：

暂无

中图分类号：

R654.3 [血管];

学科分类号：

1002 ; 100210 ;

摘要：

目的探讨血浆同型半胱氨酸（Hcy）水平与腹主动脉瘤的相关性。方法回顾性分析2011年7月2012年7月入住我院血管外科经CT诊断为腹主动脉瘤患者（病例组）58例,另选健康体检者63例为对照组。常规检测血生化指标,采用循环酶法检测Hcy水平。结果与对照组比较,病例组高同型半胱氨酸血症（HHcy）发生率明显升高（65.5%vs 27.0%,P<0.01）,Hcy水平明显升高[（19.02±9.80）μmol/L vs（13.37±4.54）μmol/L,P<0.01]。多元logistic回归分析显示,HHcy较非HHcy发生腹主动脉瘤的风险增加4.12倍（OR=5.12,95%CI:2.33～11.27,P=0.00）。调整相关危险因素后,未明显改变相关结果（OR=3.35,95%CI:1.14～9.80,P=0.03）。病例组HHcy患者与Hcy水平正常者腹主动脉瘤最大直径比较,差异无统计学意义[（5.66±1.49）cmvs（5.11±0.98）cm,P=0.18],年龄与腹主动脉瘤最大直径不相关（r=0.09,P=0.48）。结论 HHcy患者发生腹主动脉瘤的风险更大。降低Hcy水平可能有助于减缓腹主动脉瘤的发展。

引用

页码：497 / 499

页数：3

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