酚类抗氧化剂清除自由基活性的理论表征与应用

被引:63
作者
张红雨
陈德展
机构
[1] 山东师范大学生物系!济南,山东师范大学化学系!济南
关键词
抗氧化剂; 自由基; 构效关系;
D O I
暂无
中图分类号
Q617 [生物结构理论];
学科分类号
071011 ;
摘要
筛选高效、低毒、价廉的抗氧化剂一直是自由基生物学的核心课题之一。由于筛选工作的复杂性与艰巨性,近来开始用理论方法加快这一过程。已发现许多理论参数与抗氧化剂清除自由基速率常数的对数有良好的相关性,其中尤以表征O -H解离能的ΔHOF值研究得最深入。借助这一理论指标可解释酚类抗氧化剂的构效关系,对复杂抗氧化体系中抗氧化剂的活性差异也能给予较好的预测,而且还可指导新型抗氧化剂的理论构建。至此这一理论指标的有效性得到了初步验证。
引用
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页码:1 / 9
页数:9
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