动脉粥样硬化发病机制和药物干预的研究现状

被引:12
作者
缪薇
朱榆红
机构
[1] 昆明医学院第二附属医院神经内科
关键词
动脉粥样硬化; 斑块稳定性; 他汀类药物; 抗氧化剂;
D O I
暂无
中图分类号
R543.12 [];
学科分类号
1002 ; 100201 ;
摘要
动脉粥样硬化是心脑血管事件发生的共同基础,是造成心脑血管疾病和死亡的重要因素。炎症、氧化应激被认为是动脉粥样硬化发生和发展的核心机制。动脉粥样硬化不稳定性斑块的破损是缺血性卒中和心肌梗死的主要发病机制。研究动脉粥样硬化的发病机制及斑块的稳定性,采用有效治疗手段,真正达到有效预防和治疗动脉粥样硬化有着重要的意义,也是目前研究热点。
引用
收藏
页码:401 / 404
页数:4
相关论文
共 17 条
[1]   PAS综合疗法对兔动脉粥样硬化的干预 [J].
王素香 ;
王拥军 ;
尹洪超 ;
卫景沛 ;
梁宪红 ;
林金喜 ;
梁德君 .
中国动脉硬化杂志 , 2007, (07) :542-543
[2]   颈动脉粥样硬化患者血管内皮功能及普罗布考干预研究 [J].
陈德友 ;
范利 ;
刘涛 .
实用老年医学, 2006, (02) :98-100
[3]   Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population [J].
Afzal, Ali R. ;
Kiechl, Stefan ;
Daryani, Yousef P. ;
Weerasinghe, Arusha ;
Zhang, Yang ;
Reindl, Markus ;
Mayr, Agnes ;
Weger, Siegfried ;
Xu, Qingbo ;
Willeit, Johann .
STROKE, 2008, 39 (07) :1972-1978
[4]  
AGI-1067, a novel vascular protectant, anti-inflammatory drug and mild antiplatelet agent for treatment of atherosclerosis[J] . Serebruany,Malinin,Eisert,Ong.Expert Review of Cardiovascular Therapy . 2007 (4)
[5]   Potential mechanisms of stroke benefit favoring losartan in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study [J].
Devereux, Richard B. ;
Dahlof, Bjorn .
CURRENT MEDICAL RESEARCH AND OPINION, 2007, 23 (02) :443-457
[6]   The role of hypertriglyceridemia in atherosclerosis [J].
Le N.-A. ;
Walter M.F. .
Current Atherosclerosis Reports, 2007, 9 (2) :110-115
[7]  
Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data[J] . Alan D Lopez,Colin D Mathers,Majid Ezzati,Dean T Jamison,Christopher JL Murray.The Lancet . 2006 (9524)
[8]   Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency [J].
Suarna, Cacang ;
Wu, Ben J. ;
Choy, Katherine ;
Mori, Trevor ;
Croft, Kevin ;
Cynshi, Osamu ;
Stocker, Roland .
FREE RADICAL BIOLOGY AND MEDICINE, 2006, 41 (05) :722-730
[9]   Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis [J].
Matsuura, Eiji ;
Kobayashi, Kazuko ;
Tabuchi, Masako ;
Lopez, Luis R. .
PROGRESS IN LIPID RESEARCH, 2006, 45 (06) :466-486
[10]   Diagnosis of thin-cap fibroatheromas by a self-contained intravascular magnetic resonance Imaging probe in ex vivo human aortas and in situ coronary arteries [J].
Schneiderman, J ;
Wilensky, RL ;
Weiss, A ;
Samouha, E ;
Muchnik, L ;
Chen-Zion, M ;
Ilovitch, M ;
Golan, E ;
Blank, A ;
Flugelman, M ;
Rozenman, Y ;
Virmani, R .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2005, 45 (12) :1961-1969