大鼠短暂脑缺血后行为学研究

被引：9

作者：

魏佑震

姚志彬

陈以慈

机构：

[1] 泰山医学院解剖学教研室脑研究室,中山医科大学解剖学教研室脑研究室,中山医科大学解剖学教研室脑研究室,

来源：

中国行为医学科学 | 1996年 / 01期

关键词：

脑缺血; 海马; 水迷宫; 学习; 记忆;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

本文利用 Morris 水迷宫对大鼠脑缺血20分钟经短期(10天)和长期(90天)再灌流后进行了空间学习、记忆的研究。脑缺血采用四血管结扎模型。结果表明:脑缺血后再灌流10天大鼠只在定位航行试验中显示学习过程减慢,而在空间探索试验中没有显示记忆损伤;经90天再灌大鼠则在定位航行试验和空间探索试验中表现出显著的学习、记忆障碍。形态学证明脑缺血20分钟再灌10天,海马细胞丢失仍局限于 CA1区,而经90天再灌后,细胞丢失扩展到 CA3。认为行为学上的这种变化归因于海马的形态学改变。

引用

页码：2 / 4+55 +55

页数：4

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