PARP的结构、功能及其与DNA损伤的关系

被引：7

作者：

李凡 ^{[1
]}

廖志钢 ^{[2
]}

机构：

[1] 河南科技大学法医学系

[2] 四川大学华西基础医学与法医学院

来源：

河南科技大学学报(医学版) | 2005年 / 04期

关键词：

PARP; DNA损伤; 法医学;

D O I：

10.15926/j.cnki.issn1672-688x.2005.04.046

中图分类号：

Q55 [酶];

学科分类号：

071010 ; 081704 ;

摘要：

目的了解PARP的结构和功能,探讨在DNA损伤中的作用。方法查阅国内外相关文献,对PARP的结构、功能及其在DNA损伤中的作用进行综述。结果PARP在DNA损伤中有规律性表达,发挥重要作用。结论对研究细胞凋亡有意义。

引用

页码：312 / 314

页数：3

共 7 条

[1]

An enzymatic assay for poly(ADP-ribose)polymerase-1(PARP-1)via the chemical quantitionof NAD+:application to the high-throughput screening of smallmolecules as potential inhibitors. Karson S,Putt,Paul J Hergenrother. Analytical Biochemistry . 2004

[2]

Modulation of ATPlevels alters the of hydrogen peroxide-induced cell death in primarycortical cultures:effects of putative neurprotective agents. Funan Huang,Mohan C,Vemuri J S Schneider. Brain Research . 2004

[3]

Caspase andupstream mechanisms in central nervous system ischemic injury. Michael A,Moskowitz,Dean A Le,Michael J Whalen. International Congress Series . 2003

[4]

PARPgene expression∶control at many levels. Hans-Rudolf Hotz,Susanne Biebinger,John Flaspohler,et al. Molecular and Biochemi-cal Parasitology . 1998

[5]

PAPRcleavage,DNA fragmention,and pyknosis during excitotoxin-inducedneuronal death. Karen L Gilliams-Francis,Aurora A Quaye,Janice R Naegele. Experimental Neurology . 2003

[6]

Chromosomal DNA fragmentation in apoptosis andnecrosis induced by oxidative stress. Yoshihiro Higuchi. Biochemical Pharmacology . 2003

[7]

Modulation of poly(ADP-ribosy-lation)in apoptotic cells. A Ivana Scovassa,Marc Diederich. Biochemical Pharmacology . 2004

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