扩张型心肌病抗心肌细胞膜自身抗体的初步研究

被引:7
作者
廖玉华
涂源淑
李淑莉
机构
[1] 同济医科大学心血管病研究所内科,同济医科大学心血管病研究所内科,同济医科大学附属协和医院传染科,
关键词
扩张型心肌病; 免疫转印; 心肌细胞膜; 自身抗体;
D O I
10.13201/j.issn.1001-1439.1993.03.001
中图分类号
学科分类号
摘要
应用免疫转印技术检测21例DCM患者血清中抗MCM抗体,并与对照组19例作比较,结果发现,DCM患者血清中可检出抗MCM52KD(阳性率57.14%)、87kD(33.33%)、59kD(23.81%)和48kD(19.05%)各组份的自身抗体;而对照组血清则均为阴性。自身抗体所针对的靶抗原可能包括心肌细胞膜钙通道和β1-肾上腺素能受体。本研究提示,自身免疫反应可能参与DCM的发病机制,检测抗MCM自身抗体可作为DCM的重要诊断指标。
引用
收藏
页码:131 / 133
页数:3
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