氯吡格雷用于急性非致残性脑血管事件高危人群临床研究结果解读

被引:13
作者
王伊龙
孟霞
赵性泉
王拥军
机构
[1] 首都医科大学附属北京天坛医院神经内科
关键词
短暂性脑缺血发作; 轻型卒中; CHANCE研究;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
短暂性脑缺血发作(TIA)和轻型卒中具有发病率高、复发率高,复发后致残率、病死率高,但又易被忽视的特点。目前TIA和轻型卒中的国际标准化治疗是使用阿司匹林,但即使在阿司匹林的治疗下,其早期(90 d)复发率也高达10%20%。众多现存循证医学证据的分析结果提示,早期TIA和轻型卒中是适宜氯吡格雷联合阿司匹林(双联)治疗的最佳状态,可能比单独使用阿司匹林治疗获得更多收益。因此开展的氯吡格雷用于急性非致残性脑血管事件高危人群的临床研究(CHANCE),其目的是比较双联治疗与单阿司匹林治疗早期TIA和轻型卒中的有效性和安全性。研究结果证明双联治疗较单阿司匹林治疗90 d卒中复发风险减低32%,且不增加出血风险。
引用
收藏
页码:180 / 182
页数:3
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