美金刚治疗中重度阿尔茨海默病研究进展

被引：2

作者：

陈点点 ^{[1
]}

冯超英 ^{[2
]}

刘桂花 ^{[2
]}

机构：

[1] 北京军区总医院肿瘤科

[2] 解放军白求恩国际和平医院药剂科

来源：

临床误诊误治 | 2011年 / 24卷 / 10期

关键词：

美金刚; 阿尔茨海默病; 药物疗法; 生物医学研究;

D O I：

暂无

中图分类号：

R749.16 [];

学科分类号：

100203 ;

摘要：

<正>阿尔茨海默病(Alzheimer's disease,AD)是一种以学习、记忆和认知功能受损为主要特征的进行性神经系统疾病,是老年期痴呆最常见的神经退行性病变。AD的具体发病机制尚未明确,但随着近年神经药理学、生物化学及分子生物学等学科的迅猛发展及相互渗透,关于AD发病机制的研究也取得很大进展,并据此提出了很多不同的治疗方案[1]。N-甲基-D-天门冬氨酸(NMDA)受体阻滞剂——美金刚(Memantine,MEM)是临床上继乙酰胆碱酯酶抑制剂(AchEIs)后又

引用

页码：95 / 96

页数：2

共 10 条

[1] 盐酸美金刚治疗阿尔茨海默病多中心随机对照临床试验 [J].

胡洪涛 ;

张振馨 ;

姚景莉 ;

余慧贞 ;

王荫华 ;

汤洪川 ;

冀成君 ;

徐涛 .

中华内科杂志, 2006, (04) :277-280

[2] Long-term course and effectiveness of combination therapy in Alzheimer disease [J].

Atri, Alireza ;

Shaughnessy, Lynn W. ;

Locascio, Joseph J. ;

Growdon, John H. .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2008, 22 (03) :209-221

[3] Cost-effectiveness of memantine compared with standard care in moderate-to-severe Alzheimer disease in Canada [J].

Gagnon, Micheline ;

Rive, Benoit ;

Hux, Margaret ;

Guilhaume, Chantal .

CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2007, 52 (08) :519-526

[4]

Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system - too little activation is bad, too much is even worse[J] . Neuropharmacology . 2007 (6)

[5] Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-D-aspartate receptors by memantine [J].

Gilling, K. E. ;

Jatzke, C. ;

Parsons, C. G. .

NEUROPHARMACOLOGY, 2007, 53 (03) :415-420

[6]

A 24-week Randomized, Controlled Trial of Memantine in Patients With Moderate-to-severe Alzheimer Disease[J] . Christopher H. van Dyck,Pierre N. Tariot,Barnett Meyers,E. Malca Resnick.Alzheimer Disease & Associated Disorders . 2007 (2)

[7]

Cost-effectiveness of memantine in community-based Alzheimer’s disease patients: an adaptation in Spain[J] . Fernando Antonanzas,Benoit Rive,Josep M. Badenas,Susana Gomez-Lus,Chantal Guilhaume.The European Journal of Health Economics . 2006 (2)

[8]

Memantine Treatment in Mild to Moderate Alzheimer Disease: A 24-Week Randomized, Controlled Trial[J] . Elaine R. Peskind,Steven G. Potkin,Nunzio Pomara,Brian R. Ott,Stephen M. Graham,Jason T. Olin,Scott McDonald.American Journal of Geriatric Psychiatry . 2006 (8)

[9]

Cost-effectiveness of memantine for moderate to severe Alzheimer's disease in Sweden[J] . American Journal of Geriatric Pharmacotherapy . 2005 (2)

[10] Treatments for Alzheimer disease [J].

Potyk, D .

SOUTHERN MEDICAL JOURNAL, 2005, 98 (06) :628-635

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