腔隙性脑梗死患者脑微出血与循环内皮微粒的相关性研究

被引：17

作者：

孔德燕

机构：

[1] 广西中医药大学附属瑞康医院脑病科

来源：

中华老年心脑血管病杂志 | 2015年 / 17卷 / 06期

关键词：

脑梗死; 脑出血; 磁共振成像; 危险因素;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨腔隙性脑梗死患者脑微出血(CMB)与血浆内皮微粒(EMP)的关系。方法选择首次发病3个月后的腔隙性脑梗死患者84例,根据磁敏感检测结果分为CMB组33例和无CMB组51例,收集2组患者的临床基线资料,并通过流式细胞仪检测其血浆CD31+/CD42-EMP水平。结果 CMB组EMP水平明显高于无CMB组[(451.93±94.46)×106/L vs(310.93±55.47)×106/L,P=0.000]。CMB严重程度与EMP呈正相关(r=0.817,P=0.000)。二分类logistic回归分析显示,在控制了年龄、高血压、纤维蛋白原等混杂因素影响后,EMP升高仍是影响CMB发病的危险因素。结论血浆EMP升高是影响CMB发病的独立危险因素,EMP检测可作为临床预测脑梗死患者是否合并CMB的指标。

引用

页码：610 / 612

页数：3

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