内质网应激

被引:31
作者
林丽
唐朝枢
袁文俊
机构
[1] 第二军医大学基础医学部生理学教研室,北京大学医学部生理学与病理生理学系,第二军医大学基础医学部生理学教研室上海,北京,上海
关键词
内质网; 应激; 未折叠蛋白反应;
D O I
暂无
中图分类号
R33 [人体生理学];
学科分类号
1001 ;
摘要
内质网应激表现为内质网腔内错误折叠与未折叠蛋白聚集以及Ca2 +平衡紊乱 ,可激活未折叠蛋白反应、内质网超负荷反应和caspase 12介导的凋亡通路等信号途径 ,既能诱导糖调节蛋白(glucose regulatedprotein 78kD ,GRP78)、GRP94等内质网分子伴侣表达而产生保护效应 ,亦能独立地诱导细胞凋亡。内质网应激直接影响应激细胞的转归 ,如适应、损伤或凋亡。
引用
收藏
页码:333 / 335
页数:3
相关论文
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Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6. Parker R,Phan T,Baumeister P,et al. Molecular and Cellular Biology . 2001
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