急性脑梗死患者血管内皮生长因子与自由基SOD、MDA的临床研究

被引：16

作者：

何建明 ^{[1
]}

李玉蓉 ^{[1
]}

韦英秀 ^{[1
]}

胡宏波 ^{[2
]}

尹琦 ^{[2
]}

机构：

[1] 柳州市柳铁中心医院神经内科

[2] 柳州市柳铁中心医院检验科

来源：

现代生物医学进展 | 2010年 / 10卷 / 12期

关键词：

急性脑梗死; 血管内皮细胞生长因子; 超过氧化物歧化酶; 丙二醛;

D O I：

10.13241/j.cnki.pmb.2010.12.063

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的:探讨血管内皮生长因子(vascular endothelial growth factor,VEGF)、自由基SOD和MDA在急性脑梗死发病中的作用。方法:分别采用双抗体夹心ELISA法、黄嘌呤氧化法和比色法动态测定60例急性脑梗死患者及正常对照者起病后或入组后第1天、3天、7天、14天外周血清VEGF和SOD、MDA水平,分析其关系。结果:脑梗死组各时间点血清VEGF的水平明显高于正常对照组(P<0.01),至病程第7天达高峰,以后逐渐下降,至14天仍维持较高水平,差异有统计学意义(P<0.01);脑梗死组发病第1天及第3天,SOD水平明显低于对照组,MDA水平明显高于对照组(P<0.01),在第7天及14天,两组比较无显著性差异;患者血清VEGF水平在发病第3、14天随着梗死面积增大及病情严重程度而升高,三组比较有显著性差异(P<0.01),而血清SOD和MDA水平只在发病第3天才与梗死面积及病情严重程度有变化(P<0.01)。结论:VEGF、MDA和SOD共同参与脑梗死急性期血管病理损伤过程,VEGF可作为评估急性脑梗死患者病情轻重和预后的客观指标。

引用

页码：2295 / 2298

页数：4

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