低分子肝素预防人工髋、膝关节置换术后下肢深静脉血栓形成的研究

被引：365

作者：

杨刚

吕厚山

高健

寇伯龙

袁燕林

徐斌

机构：

[1] 北京医科大学人民医院关节病诊疗研究中心

[2] 北京医科大学人民医院放射科

来源：

中华外科杂志 | 2000年 / 01期

关键词：

血栓性静脉炎; 人工关节; 肝素,低分子量;

D O I：

暂无

中图分类号：

R687.4 [关节手术];

学科分类号：

1002 ; 100210 ;

摘要：

目的　对比观察采用低分子肝素预防人工髋、膝关节置换术 (THR、TKR)后下肢深静脉血栓形成 (DVT)的临床效果。　方法　将 1997年 11月～ 1999年 3月行人工髋膝关节置换术的患者随机分为未用药组和用药组 ,其中未用药组共 47例患者 ,6 2例关节置换 (34膝 ,2 8髋 ) ,未预防性使用低分子肝素抗凝 ;用药组共 31例患者 ,36例关节置换 (19膝 ,17髋 ) ,围手术期给予低分子肝素预防治疗。两组患者均于术后行下肢静脉造影检查。　结果　用药组DVT总发生率为 19 4% ,其中TKR术后发生率为 2 6 3% ,THR术后发生率为 11 8% ;未用药组DVT总发生率为 48 4% ,其中TKR术后发生率为 5 5 9% ,THR术后发生率为 39 3% ;两组相比差异有显著性意义 (P <0 0 5 )。用药组近端DVT的发生率为 2 8% ,较未用药组为 19 4% ,两组差异亦有显著性意义 (P <0 0 5 )。用药组未发现术中及术后出血增多等现象以及由此引发的不良反应。　结论　低分子肝素可显著降低人工关节置换术后下肢深静脉血栓的发生率 ,而且具有良好的安全性。

引用

页码：24 / 26

页数：3

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