内皮祖细胞治疗冠脉粥样硬化前景

被引：5

作者：

林杰

张怀勤

机构：

[1] 温州医学院附属第一医院心血管内科,温州医学院心血管生物与基因研究所

来源：

中国全科医学 | 2007年 / 17期

关键词：

内皮祖细胞; 冠状动脉硬化; 心血管疾病; 危险因素;

D O I：

暂无

中图分类号：

R543 [血管疾病];

学科分类号：

1002 ; 100201 ;

摘要：

冠脉内皮的损伤是冠脉粥样硬化的开始,冠脉粥样硬化斑块破裂形成血栓是急性冠脉狭窄引起急性冠脉综合征(ACS)的主要病理基础。内皮祖细胞具有干祖细胞的增殖、分化的特点,在一定的细胞因子诱导下可以分化为血管内皮细胞,参与血管新生。心血管疾病危险因素诱发冠脉粥样硬化部分是通过显著减少循环中的内皮祖细胞的数量,同时损伤内皮祖细胞修复内皮的功能来实现的。内皮祖细胞对损伤的血管内皮的修复作用可阻止动脉粥样硬化的进程。本文对内皮祖细胞治疗冠脉粥样硬化的前景做一综述。

引用

页码：1466 / 1469

页数：4

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