血栓性脑梗死患者血清同型半胱氨酸水平变化及意义

被引:1
作者
曹丽丽
崔才三
麻琳
迟兆富
机构
[1] 山东大学齐鲁医院,山东大学齐鲁医院,山东大学齐鲁医院,山东大学齐鲁医院山东济南,山东济南,山东济南,山东济南
关键词
同型半胱氨酸; 脑梗死; 危险因素; 痴呆;
D O I
暂无
中图分类号
R743.32 [脑血栓形成];
学科分类号
1002 ;
摘要
为探讨血栓性脑梗死 (TCI)患者血清同型半胱氨酸 H(e)水平与其他中风危险因素之间的关系 ,用高效液相色谱法 (HPL C)测定脑梗死患者血清 H(e) ,简易智力状态检查法 (MMSE)评定痴呆 ,分析脑梗死患者血清 H (e)水平与相关因素之间的关系。结果显示 ,TCI患者血清 H (e)显著高于脑栓塞 (ECI)组和对照组 ,且与高血压、糖尿病、高血脂、性别、年龄无关 ;脑梗死中痴呆患者血清 H(e)显著高于非痴呆患者。提示血清 H(e)升高为独立于高血压、糖尿病和高血脂之外脑血管疾病的重要危险因素之一 ,且参与痴呆的病理过程
引用
收藏
页码:18 / 19
页数:2
相关论文
共 7 条
[1]  
Nonfasting plasma total homocysteine levels and stroke incidence in elderly persons:the Framingham Study. Bostom AG,Rosenberg IH,Silbershatz H,et al. Annals of Internal Medicine . 1999
[2]  
The relationship of plasma total homocysteine levels to prevalent cardiovascular disease in older patients with ischemic stroke. Adunsky A,Weitzman A,Fleissig Y,et al. Age and Ageing . 2000
[3]  
Serum total homocysteine concentrations in adolesent and adult Americans: results from the third National Health and Nutrition Examinaion survey. Jacques PF,Rosenberg IH,Roger G,et al. The American Journal of Clinical Nutrition . 1999
[4]  
Association between high Homocyst ( e ) ine and ischemic stroke due to large and small artery disease but not other etiologic subtypes of ischemic stroke. Eikelboom JW,Hankey FJ,Anand SS,et al. Stroke . 2000
[5]  
Homocysteine and ischaemic stroke in men: the Caerphilly study. Fallon UB,Elwood P,Ben-Shlomo Y,et al. Journal of Epidemiology and Community Health . 2001
[6]  
Prospective study of total homocyst ( e ) ine concentration and risk of stroke in middle-aged British men. Perry IJ,Refsum H,Morris RW,et al. The Lancet . 1995
[7]  
Homocysteine elicits a DNA damage response in neurons that promotes apotosis and hypersensitivity to excitotoxicity. Kruman H,Culmsee C,Chan SL,et al. Journal of the Neurological Sciences . 2000