急性缺血性脑卒中血管内治疗进展

被引:29
作者
沈芳 [1 ]
刘康永 [2 ]
孙晓江 [1 ]
机构
[1] 上海交通大学附属第六人民医院神经内科
[2] 上海市浦东新区周浦医院神经内科
关键词
急性缺血性脑卒中; 静脉溶栓; 动脉溶栓; 机械取栓; 机械碎栓; 支架成形;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
脑卒中是神经内科常见疾病之一,具有发病率高、复发率高、病死率高和致残率高的特点。重组组织型纤维蛋白酶原激活剂(rt-PA)是自1996年以来唯一被美国食品和药物管理局(FDA)批准用于急性缺血性脑卒中(AIS)溶栓治疗的药物,但因静脉溶栓的治疗时间窗狭窄(<4.5 h)、大血管再通率低及出血风险限制了rt-PA的使用,导致全球范围内的溶栓治疗率一直很低。近年,相关血管内治疗技术有了快速发展,显著提高了闭塞血管的开通率。文中就静脉溶栓、动脉溶栓、机械取栓、机械碎栓、支架成形等治疗技术的相关情况进行介绍。
引用
收藏
页码:331 / 337
页数:7
相关论文
共 14 条
[1]  
Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials[J] . Jonathan Emberson,Kennedy R Lees,Patrick Lyden,Lisa Blackwell,Gregory Albers,Erich Bluhmki,Thomas Brott,Geoff Cohen,Stephen Davis,Geoffrey Donnan,James Grotta,George Howard,Markku Kaste,Masatoshi Koga,Ruediger von Kummer,Maarten Lansberg,Richard I Lindley,Gordon Murray,Jean Marc Olivot,Mark
[2]   Non-pharmacological strategies for the treatment of acute ischaemic stroke [J].
Hennerici, Michael G. ;
Kern, Rolf ;
Szabo, Kristina .
LANCET NEUROLOGY, 2013, 12 (06) :572-584
[3]  
Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010[J] . Gonghuan Yang,Yu Wang,Yixin Zeng,George F Gao,Xiaofeng Liang,Maigeng Zhou,Xia Wan,Shicheng Yu,Yuhong Jiang,Mohsen Naghavi,Theo Vos,Haidong Wang,Alan D Lopez,Christopher JL Murray.The Lancet . 2013 (9882)
[4]  
Implementation and Outcome of Thrombolysis with Alteplase 3 to 4.5 h After Acute Stroke in Chinese Patients[J] . Xiao‐Ling Liao,Chun‐Xue Wang,Yi‐Long Wang,Chun‐Juan Wang,Xing‐Quan Zhao,Li‐Qun Zhang,Li‐Ping Liu,Yue‐Song Pan,Yong‐Jun Wang.CNS Neurosci Ther . 2012 (1)
[5]   Mechanical Thrombolysis and Stenting in Acute Ischemic Stroke [J].
Gralla, Jan ;
Brekenfeld, Caspar ;
Mordasini, Pasquale ;
Schroth, Gerhard .
STROKE, 2012, 43 (01) :280-285
[6]   Self-Expandable Stents in the Treatment of Acute Ischemic Stroke Refractory to Current Thrombectomy Devices [J].
Linfante, Italo ;
Samaniego, Edgar A. ;
Geisbuesch, Philipp ;
Dabus, Guilherme .
STROKE, 2011, 42 (09) :2636-2638
[7]  
Mechanical Thrombectomy With the Solitaire AB Device in Large Artery Occlusions of the Anterior Circulation: A Pilot Study[J] . Stroke . 2010 (8)
[8]  
Implementation and outcome of thrombolysis with alteplase 3–4·5 h after an acute stroke: an updated analysis from SITS-ISTR[J] . Niaz Ahmed,Nils Wahlgren,Martin Grond,Michael Hennerici,Kennedy R Lees,Robert Mikulik,Mark Parsons,Risto O Roine,Danilo Toni,Peter Ringleb.Lancet Neurology . 2010 (9)
[9]  
Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials[J] . Kennedy R Lees,Erich Bluhmki,Rüdiger von Kummer,Thomas G Brott,Danilo Toni,James C Grotta,Gregory W Albers,Markku Kaste,John R Marler,Scott A Hamilton,Barbara C Tilley,Stephen M Davis,Geoffrey A Donnan,Werner Hacke.The Lancet . 2010 (9727)
[10]  
Efficacy of Intra-Arterial Fibrinolysis for Acute Ischemic Stroke: Meta-Analysis of Randomized Controlled Trials[J] . Meng Lee,Keun-Sik Hong,Jeffrey L. Saver.Stroke . 2010 (5)