动脉持续灌注罂粟碱对兔脑血管痉挛的实验研究

被引：13

作者：

芦奕

孙丕通

惠国桢

白景阳

许友松

吴智远

机构：

[1] 苏州大学附属第一医院神经外科

[2] 大连医科大学附属第一医院神经外科

来源：

江苏医药 | 2004年 / 05期

关键词：

蛛网膜下腔出血; 脑血管痉挛; 罂粟碱; 兔;

D O I：

10.19460/j.cnki.0253-3685.2004.05.007

中图分类号：

R743.35 [蛛网膜下腔出血];

学科分类号：

1002 ;

摘要：

目的　观察动脉持续灌注罂粟碱对蛛网膜下腔出血后脑血管痉挛的作用。方法　日本大耳白兔用“二次枕大池注血法”制作症状性脑血管痉挛模型。经一侧椎动脉用微量泵持续灌注罂粟碱。结果　持续灌注罂粟碱 2天、5天基底动脉造影直径和神经系统损害症状级别与治疗前比较有明显改善 (P <0 0 1) ;对照组无明显改善 (P >0 0 5 )。对照组基底动脉、脑组织结构改变明显 ,治疗组基本正常。结论　动脉持续灌注罂粟碱有预防迟发性脑血管痉挛作用。

引用

页码：334 / 336+320 +320

页数：4

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