脑源性神经生长因子功能及细胞内信号传导通路

被引：13

作者：

刘丽

徐格林

樊新颖

机构：

[1] 南京军区南京总医院神经内科

来源：

脑与神经疾病杂志 | 2011年 / 19卷 / 02期

关键词：

BDNF; 信号通路; 突触可塑性; 谷氨酸释放; 神经元凋亡; 脑源性神经生长因子; TrkB; 功能;

D O I：

暂无

中图分类号：

R741.05 [神经病治疗学];

学科分类号：

1002 ;

摘要：

<正>神经营养因子包括神经生长因子(nerve groth factoe,NGF),脑源性神经生长因子(brain-derived neurotrophic factor,BDNF),神经营养因子-3(neurotrophin-3,NT-3),神经营养因子-4/5(neurotrophin-4/5,NT-4/5)等。这些因子可以作为信号传导通路的配体与其受体酪氨酸蛋白激酶(Trk)高亲和力结合,也可以与分子量为75KDNT受体(75KDNT receptor,p75)以低亲和力结合。Trk包括TrkA、TrkB、TrkC等3种,神经营养因子与其Trk结合具有明显的选择性,其中NGF可与TrkA特异性结合,

引用

页码：158 / 161

页数：4

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