阿托伐他汀对非ST段抬高型心肌梗死患者血清炎性因子水平影响

被引：7

作者：

陈克俭 ^{[1
]}

刘凯 ^{[2
]}

胡丽丽 ^{[2
]}

机构：

[1] 咸宁市第一人民医院内科

[2] 武汉大学人民医院心内科

来源：

临床心血管病杂志 | 2012年 / 28卷 / 01期

关键词：

非ST段抬高型心肌梗死; 阿托伐他汀; 高敏C反应蛋白; 白细胞介素6; 肿瘤坏死因子-α;

D O I：

10.13201/j.issn.1001-1439.2012.01.015

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的:探讨早期应用阿托伐他汀对非ST段抬高型心肌梗死患者血清高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)和肿瘤坏死因子-α(TNF-α)的影响。方法:将100例非ST段抬高型心肌梗死患者随机分为治疗组和对照组各50例,2组均经常规治疗,治疗组在此基础上给予阿托伐他汀20mg/d,治疗1个月后用ELISA法检测2组治疗前后血清hs-CRP、IL-6和TNF-α水平。结果:与对照组比较,治疗组可明显降低血清hs-CRP、IL-6、TNF-α水平,差异有统计学意义(P<0.05)。结论:非ST段抬高型心肌梗死患者早期应用阿托伐他汀治疗可以使hs-CRP、IL-6、TNF-α水平显著下降,炎症反应明显减轻,稳定动脉粥样硬化斑块。

引用

页码：46 / 48

页数：3

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