不同剂量瑞舒伐他汀钙治疗冠状动脉慢血流的临床效果研究

被引：13

作者：

叶廖沙

石宇杰

李俊峡

张健

孙琪

机构：

[1] 北京军区总医院心血管疾病研究所

来源：

临床误诊误治 | 2015年 / 28卷 / 01期

关键词：

瑞舒伐他汀钙; 冠状动脉疾病; 血流速度; 冠状动脉造影;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

目的评价瑞舒伐他汀钙对冠状动脉慢血流(coronary slow flow,CSF)的治疗效果及其与剂量的关系。方法选取2010年1月—2013年1月我院经冠状动脉造影确诊为CSF患者90例,随机分为高剂量瑞舒伐他汀钙组(高剂量组)、低剂量瑞舒伐他汀钙组(低剂量组)及对照组各30例,前两组在常规治疗基础上分别给予瑞舒伐他汀钙20 mg/d、10 mg/d,对照组仅予基础治疗。治疗4周后,采用心肌梗死溶栓血流帧数平均值(M-TFC)比较治疗前后各组冠状动脉血流速度;根据心绞痛发作次数改善情况,评价各组心绞痛治疗总有效率。结果治疗4周后,3组M-TFC较治疗前均明显下降,且治疗后高剂量组、低剂量组M-TFC均低于对照组,高剂量组M-TFC低于低剂量组,差异均有统计学意义(P<0.01);高剂量组、低剂量组心绞痛改善总有效率均明显高于对照组(χ2=6.2388,P=0.0125;χ2=4.8000,P=0.0285),而高剂量组与低剂量组心绞痛改善总有效率比较差异无统计学意义(χ2=0.0113,P=0.7386)。结论在常规扩血管药物治疗基础上联用瑞舒伐他汀钙,可有效改善CSF患者冠状动脉血流速度,明显提高心绞痛治疗有效率,且瑞舒伐他汀钙20 mg/d强化治疗更有效。

引用

页码：91 / 94

页数：4

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