福辛普利、依贝沙坦及二者合用对心肌梗死后心室重塑影响的实验研究

被引：7

作者：

张瑞英

孙艺红

黄永麟

机构：

[1] 哈尔滨医科大学第一临床医学院心内科,哈尔滨医科大学第一临床医学院心内科,哈尔滨医科大学第一临床医学院心内科,,

来源：

中华心血管病杂志 | 2002年 / 10期

关键词：

心肌梗死; 心室重塑; 血管紧张素; 胶原;

D O I：

暂无

中图分类号：

R542.22 [];

学科分类号：

1002 ; 100201 ;

摘要：

目的　对比福辛普利、依贝沙坦及二者合用对大鼠心肌梗死后心室重塑的影响。方法通过结扎冠状动脉左前降支诱导大鼠心肌梗死 ,心肌梗死后 2 4h将大鼠随机分为 :(1)安慰剂组 ;(2 )福辛普利组 ;(3)依贝沙坦组 ;(4 )福辛普利 +依贝沙坦组 ;另设假手术组。 2周后检查以下指标 :(1)平均动脉压 ,左室舒张末压 ;(2 )心室重量 /体重 ;(3)非梗死区胶原含量 ;(4 )非梗死区非心肌细胞增生数量。结果　安慰剂组与假手术组相比左室舒张末压增加 (P <0 0 5 ) ,且心室重量 /体重、非梗死区胶原含量及非心肌细胞增生数量增加显著 (P <0 0 1)。福辛普利组和依贝沙坦组与安慰剂组相比平均动脉压下降、心室重量 /体重及非心肌细胞增生数量下降 ,二者合用与安慰剂组比较以上指标下降显著 (P <0 0 1) ;两药单用和合用与安慰剂组相比左室舒张末压下降 (P <0 0 5 )。两药单独和联合应用均阻止了非梗死区胶原沉积 (P <0 0 1,与安慰剂组相比 ) ,两个单独用药组高于假手术组 (P <0 0 5 ) ,而联合治疗组与假手组间无统计学差异。福辛普利组、依贝沙坦组及二者合用组三者间各指标差异均无统计学意义。结论　福辛普利和依贝沙坦均可限制心肌梗死后心肌肥大、抑制左室非梗死区胶原沉积和非心肌细胞增生 ;二者合用 2周未见上述作

引用

页码：53 / 56

页数：4

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