急性缺血性脑血管病患者血清ox-LDL及PAPP-A水平与颈动脉粥样硬化的相关性研究

被引：27

作者：

生晓娜 ^{[1
,2
]}

杨扬 ^{[1
,2
]}

张晓炜 ^{[3
]}

王斌斌 ^{[1
,2
]}

艾田妹 ^{[4
]}

张国华 ^{[1
,2
]}

机构：

[1] 河北医科大学第二医院神经内科

[2] 河北省神经病学重点实验室

[3] 河北医科大学第二医院神经外科

[4] 衡水市第二人民医院

来源：

中风与神经疾病杂志 | 2015年 / 32卷 / 05期

关键词：

短暂性脑缺血发作; 急性脑梗死; 颈动脉粥样硬化; ox-LDL; PAPP-A;

D O I：

10.19845/j.cnki.zfysjjbzz.2015.05.004

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨急性缺血性脑血管病患者颈动脉粥样硬化与血清氧化型低密度脂蛋白(ox-LDL)、妊娠相关血浆蛋白A(PAPP-A)水平的关系。方法随机选取急性脑梗死患者90例和短暂性脑缺血发作(TIA)患者60例作为研究对象,随机选取健康体检者30例作为对照组。入选者均检测血清ox-LDL、PAPP-A水平。对急性脑梗死和TIA患者进行颈动脉超声检查,发现颈动脉内-中膜厚度(IMT)正常者22例,IMT增厚者47例,颈动脉斑块形成者81例,其中稳定斑块者49例,不稳定斑块者32例。比较各组血清ox-LDL及PAPP-A水平。结果急性脑梗死组血清PAPP-A及ox-LDL水平显著高于TIA组(P<0.01),后者显著高于正常对照组(P<0.01);在缺血性脑血管病患者中,颈动脉粥样硬化斑块形成者血清PAPP-A及ox-LDL水平较颈动脉IMT增厚组明显升高(P<0.01),后者高于IMT正常组(P<0.01);在颈动脉斑块形成者中,其血清PAPP-A及ox-LDL水平在不稳定斑块组高于稳定斑块组(P<0.01)。Spearman分析显示,血清PAPP-A与ox-LDL水平之间存在明显相关性(r=0.839,P<0.05);logistic回归分析显示,血清PAPP-A与ox-LDL水平是发生颈动脉粥样硬化的危险因素(OR=2.549,95%CI1.12～3.79;OR=1.317,95%CI1.15～2.11)。结论急性缺血性脑血管病患者颈动脉粥样硬化的发生和进展与ox-LDL、PAPP-A水平相关,血清ox-LDL及PAPP-A水平可在一定程度上反映急性缺血性脑血管病患者颈动脉粥样硬化的程度。两者在颈动脉甚至颅内动脉粥样硬化的形成过程中产生协同作用。

引用

页码：402 / 405

页数：4

共 9 条

[1]

A complete compilation of matrix metalloproteinase expression in human malignant gliomas[J]. Carsten Hagemann,Jelena Anacker,Ralf-Ingo Ernestus,Giles H Vince.World Journal of Clinical Oncology. 2012(05)

[2] MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A [J].

Sun, Yufa ;

Chen, Deyou ;

Cao, Lijuan ;

Zhang, Rongrong ;

Zhou, Jie ;

Chen, Haiyan ;

Li, Yinyin ;

Li, Minglong ;

Cao, Jian ;

Wang, Zhe .

CARDIOVASCULAR RESEARCH, 2013, 100 (02) :272-279

[3] Value of serum pregnancy-associated plasma protein A for predicting cardiovascular events among patients presenting with cardiac chest pain [J].

von Haehling, Stephan ;

Doehner, Wolfram ;

Jankowska, Ewa A. ;

Ponikowski, Piotr ;

Stellos, Konstantinos ;

Puntmann, Valentina O. ;

Nagel, Eike ;

Anker, Stefan D. ;

Gawaz, Meinrad ;

Bigalke, Boris .

CANADIAN MEDICAL ASSOCIATION JOURNAL, 2013, 185 (07) :E295-E303

[4]

Macrophages Generate Reactive Oxygen Species in Response to Minimally Oxidized Low-Density Lipoprotein: Toll-Like Receptor 4– and Spleen Tyrosine Kinase–Dependent Activation of NADPH Oxidase 2[J] . Yun Soo Bae,Jee Hyun Lee,Soo Ho Choi,Sunah Kim,Felicidad Almazan,Joseph L. Witztum,Yury I. Miller.Circulation Research . 2009 (2)

[5]

Pregnancy-Associated Plasma Protein-A Is Markedly Expressed by Monocyte-Macrophage Cells in Vulnerable and Ruptured Carotid Atherosclerotic Plaques[J] . Giuseppe Sangiorgi,Alessandro Mauriello,Elena Bonanno,Claus Oxvig,Cheryl A. Conover,Michael Christiansen,Santi Trimarchi,Vincenzo Rampoldi,David R. Holmes,Robert S. Schwartz,Luigi Giusto Spagnoli.Journal of the American College of Cardiology . 2006 (11)

[6]

Pregnancy-Associated Plasma Protein A and Its Endogenous Inhibitor, the Proform of Eosinophil Major Basic Protein （proMBP）, Are Related to Complex Stenosis Morphology in Patients With Stable Angina Pectoris[J] . Juan Cosin-Sales,Michael Christiansen,Paul Kaminski,Claus Oxvig,Michael T. Overgaard,Della Cole,David W. Holt,Juan Carlos Kaski.Circulation: Journal of the American Heart Association . 2004 (14)

[7] Circulating pregnancy-associated plasma protein A predicts outcome in patients with acute coronary syndrome but no troponin I elevation [J].

Lund, J ;

Qin, QP ;

Ilva, T ;

Pettersson, K ;

Voipio-Pulkki, LM ;

Porela, P ;

Pulkki, K .

CIRCULATION, 2003, 108 (16) :1924-1926

[8]

Transforming Growth Factor-β1 Modulates Oxidatively Modified LDL–Induced Expression of Adhesion Molecules: Role of LOX-1[J] . Hongjiang Chen,Dayuan Li,Tom Saldeen,Jawahar L. Mehta.Circulation Research: Journal of the American Heart Association . 2001 (12)

[9] Elevated levels of oxidized low density lipoprotein show a positive relationship with the severity of acute coronary syndromes [J].

Ehara, S ;

Ueda, M ;

Naruko, T ;

Haze, K ;

Itoh, A ;

Otsuka, M ;

Komatsu, R ;

Matsuo, T ;

Itabe, H ;

Takano, T ;

Tsukamoto, Y ;

Yoshiyama, M ;

Takeuchi, K ;

Yoshikawa, J ;

Becker, AE .

CIRCULATION, 2001, 103 (15) :1955-1960

← 1 →