补阳还五汤防治多发性硬化作用机理概述

被引：15

作者：

刘建春 ^{[1
]}

张红珍 ^{[1
]}

郭文娟 ^{[1
]}

李艳花 ^{[2
]}

刘春云 ^{[2
]}

杨春彦 ^{[1
]}

马存根 ^{[1
,2
]}

机构：

[1] 山西中医学院“”协同创新中心/神经生物学研究中心

[2] 山西大同大学脑科学研究所

来源：

中医杂志 | 2016年 / 57卷 / 13期

关键词：

多发性硬化; 补阳还五汤; 免疫调节; 抗炎; 抗过氧化; 神经保护;

D O I：

10.13288/j.11-2166/r.2016.13.019

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

多发性硬化病理特征是促炎性T细胞介导的脱髓鞘,少突胶质细胞缺失,神经胶质瘢痕形成和随后的轴突和神经元损伤。其基本中医病机是本虚标实,常见证型为气虚血瘀证,治疗应以补气,活血,祛痰、湿、瘀,通络为主。补阳还五汤是益气活血的代表方,综合分析近年相关研究,发现补阳还五汤具有抗炎抑炎、免疫调节、清除自由基和抗过氧化、保护神经和促进神经再生等作用,可为多发性硬化的预防和治疗提供新思路。

引用

页码：1155 / 1159

页数：5

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