脑缺血和再灌注损伤与防治机制的研究进展

被引：7

作者：

吴金华 ^{[1
,2
]}

马慧萍 ^{[1
]}

蒙萍 ^{[1
]}

贾正平 ^{[1
,2
]}

机构：

[1] 兰州军区兰州总医院

[2] 兰州大学药学院

来源：

药学实践杂志 | 2014年 / 32卷 / 06期

关键词：

脑缺血; 再灌注损伤; 防治; 损伤机制;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

总结脑缺血和再灌注损伤的发生和防治机制的研究进展,展望未来研究趋势。采用文献归纳总结的方法进行分析。脑缺血和再灌注造成的损伤与炎性反应、细胞内Ca2+超载、自由基的迅速增加、兴奋性氨基酸的大量释放等因素有关。防治脑缺血和再灌注损伤的机制主要有缩短缺血时间、阻断谷氨酸受体偶联的Na+和Ca2+内流、清除自由基、抑制凋亡、减轻炎症反应、促进神经元生长与修复等多个方面。多靶点联合治疗可能是防治脑缺血和再灌注损伤的一个方向。

引用

页码：401 / 404+447 +447

页数：5

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