肾素-血管紧张素系统对心血管系统疾病的网络调节

被引：16

作者：

杨慧

王红霞

李汇华

机构：

[1] 首都医科大学基础医学院病理与病理生理学系

来源：

生理科学进展 | 2013年 / 44卷 / 03期

基金：

北京市自然科学基金;

关键词：

肾素-血管紧张素系统; 心血管疾病; 网络调节;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

1002 ; 100201 ;

摘要：

肾素-血管紧张素系统(RAS)是维持血压、水和电解质平衡及心血管稳态的重要调控系统,对心血管系统疾病的发生发展至关重要。近些年,RAS研究取得了令人瞩目的成就,血管紧张素转换酶抑制剂和血管紧张素受体抑制剂已成为临床治疗高血压等心血管疾病的一线药物。众多有功能的代谢片段、酶及受体的发现,使得RAS成为一个复杂的网络调节体系。为了更好全面地认识RAS的作用机制,本文拟从酶水平、代谢物水平、受体水平及信号通路介绍RAS的主要成员及其在心血管疾病中网络调节作用。

引用

页码：183 / 187

页数：5

共 10 条

[1]

Angiotensin-(1-7) modulates renin–angiotensin system associated with reducing oxidative stress and attenuating neuronal apoptosis in the brain of hypertensive rats[J] . Teng Jiang,Li Gao,Jianquan Shi,Jie Lu,Yao Wang,Yingdong Zhang.Pharmacological Research . 2013 (1)

[2]

Angiotensin-(1–7) regulates Angiotensin II-induced VCAM-1 expression on vascular endothelial cells[J] . Feng Zhang,Jingyi Ren,Kenneth Chan,Hong Chen.Biochemical and Biophysical Research Communications . 2012

[3] New roles for renin and prorenin in heart failure and cardiorenal crosstalk [J].

Schroten, Nicolas F. ;

Gaillard, Carlo A. J. M. ;

van Veldhuisen, Dirk J. ;

Szymanski, Mariusz K. ;

Hillege, Hans L. ;

de Boer, Rudolf A. .

HEART FAILURE REVIEWS, 2012, 17 (02) :191-201

[4] Angiotensin IV displays only low affinity for native insulin-regulated aminopeptidase (IRAP) [J].

Demaegdt, Heidi ;

De Backer, Jean-Paul ;

Lukaszuk, Aneta ;

Toth, Geza ;

Szemenyei, Erzsebet ;

Tourwe, Dirk ;

Vauquelin, Georges .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2012, 26 (02) :194-197

[5] Angiotensin IV protects against angiotensin II-induced cardiac injury via AT4 receptor [J].

Yang, Hui ;

Zeng, Xiang-Jun ;

Wang, Hong-Xia ;

Zhang, Li-Ke ;

Dong, Xiao-Li ;

Guo, Shubin ;

Du, Jie ;

Li, Hui-Hua ;

Tang, Chao-Shu .

PEPTIDES, 2011, 32 (10) :2108-2115

[6]

Role of the renin–angiotensin–aldosterone system for control of arterial blood pressure following moderate deficit in total body sodium: Balance studies in freely moving dogs[J] . ErdmannSeeliger,TillLunenburg,MechthildLadwig,H WolfgangReinhardt.Clinical and Experimental Pharmacology and Physiology . 2010 (2)

[7] Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling [J].

Leda, Masaki ;

Tsuchihashi, Takatoshi ;

Ivey, Kathryn N. ;

Ross, Robert S. ;

Hong, Ting-Ting ;

Shaw, Robin M. ;

Srivastava, Deepak .

DEVELOPMENTAL CELL, 2009, 16 (02) :233-244

[8]

Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway[J] . Vijay Koka,Xiao Ru Huang,Arthur C.K. Chung,Wansheng Wang,Luan D. Truong,Hui Yao Lan.The American Journal of Pathology . 2008 (5)

[9] Involvement of AT1 angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature [J].

Dharmani, M. ;

Mustafa, M. R. ;

Achike, F. I. ;

Sim, M. K. .

PEPTIDES, 2008, 29 (10) :1773-1780

[10]

Conversion of Renal Angiotensin II to Angiotensin III Is Critical for AT2 Receptor-Mediated Natriuresis In Rats[J] . Shetal H. Padia,Brandon A. Kemp,Nancy L. Howell,Marie-Claude Fournie-Zaluski,Bernard P. Roques,Robert M. Carey.Hypertension . 2008 (2, p)

← 1 →