缺血性卒中静脉内溶栓治疗后症状性脑出血危险因素的研究进展

被引:12
作者
苏克江
安荣彪
机构
[1] 解放军第六六三九三部队门诊部
关键词
脑缺血; 溶栓,治疗性; 危险因素; 综述; 出血转化;
D O I
暂无
中图分类号
R743.3 [急性脑血管疾病(中风)];
学科分类号
1002 ;
摘要
<正>急性缺血性卒中(acute ischemic stroke,AIS)后出血转化为自然病程中严重影响预后的并发症。在目前公认的时间窗内,采用静脉内重组组织型纤溶酶原激活剂(rt-PA)或阿替普酶溶栓治疗可显著降低病死率、改善AIS患者的转归,但会增加出血转化,尤其是症状性脑出血(symptomatic intracranial hemorrhage,s ICH)[1-2]。s ICH是导致静脉内溶栓治
引用
收藏
页码:97 / 104
页数:8
相关论文
共 38 条
[1]  
Increased Blood-Brain Barrier Permeability on Perfusion Computed Tomography Predicts Hemorrhagic Transformation in Acute Ischemic Stroke[J] . Ozkul-wermester,Ozlem,Guegan-massardier,Evelyne,Triquenot,Aude,Borden,Alaina,Perot,Guillaume,Gérardin,Emmanuel.European Neurology . 2014 (1-2)
[2]   Fluid-Attenuated Inversion Recovery Hyperintensity Correlates With Matrix Metalloproteinase-9 Level and Hemorrhagic Transformation in Acute Ischemic Stroke [J].
Jha, Ruchira ;
Battey, Thomas W. K. ;
Pham, Ly ;
Lorenzano, Svetlana ;
Furie, Karen L. ;
Sheth, Kevin N. ;
Kimberly, W. Taylor .
STROKE, 2014, 45 (04) :1040-1045
[3]  
Does Sex Influence the Response to Intravenous Thrombolysis in Ischemic Stroke?: Answers From Safe Implementation of Treatments in Stroke-International Stroke Thrombolysis Register[J] . Svetlana Lorenzano,Niaz Ahmed,Anne Falcou,Robert Mikulik,Turgut Tatlisumak,Christine Roffe,Nils Wahlgren,Danilo Toni.Stroke . 2013 (12)
[4]   Baseline serum glucose concentration and symptomatic haemorrhagic transformation in non-diabetic stroke patients treated by intravenous thrombolysis [J].
Gnofam, Mayi ;
Leys, Didier ;
Ponchelle-Dequatre, Nelly ;
Bodenant, Marie ;
Henon, Hilde ;
Bordet, Regis ;
Cordonnier, Charlotte .
JOURNAL OF NEUROLOGY, 2013, 260 (11) :2786-2792
[5]   Glycosylated Hemoglobin A1 Predicts Risk for Symptomatic Hemorrhage After Thrombolysis for Acute Stroke [J].
Rocco, Andrea ;
Heuschmann, Peter U. ;
Schellinger, Peter D. ;
Koehrmann, Martin ;
Diedler, Jennifer ;
Sykora, Marek ;
Nolte, Christian H. ;
Ringleb, Peter ;
Hacke, Werner ;
Juettler, Eric .
STROKE, 2013, 44 (08) :2134-2138
[6]   Factors influencing haemorrhagic transformation in ischaemic stroke [J].
Alvarez-Sabin, Jose ;
Maisterra, Olga ;
Santamarina, Estevo ;
Kase, Carlos S. .
LANCET NEUROLOGY, 2013, 12 (07) :689-705
[7]   Hyperdense middle cerebral artery sign is associated with increased risk of hemorrhagic transformation after intravenous thrombolysis for patients with acute ischaemic stroke [J].
Zou, Ming ;
Churilov, Leonid ;
He, Anna ;
Campbell, Bruce ;
Davis, Stephen M. ;
Yan, Bernard .
JOURNAL OF CLINICAL NEUROSCIENCE, 2013, 20 (07) :984-987
[8]  
Diabetes Mellitus, Admission Glucose, and Outcomes After Stroke Thrombolysis: A Registry and Systematic Review[J] . Jean-Philippe Desilles,Elena Meseguer,Julien Labreuche,Bertrand Lapergue,Gaia Sirimarco,Jaime Gonzalez-Valcarcel,Philippa Lavallée,Lucie Cabrejo,Celine Guidoux,Isabelle Klein,Pierre Amarenco,Mikael Mazighi.Stroke . 2013 (7)
[9]   Association of CT Perfusion Parameters with Hemorrhagic Transformation in Acute Ischemic Stroke [J].
Jain, A. R. ;
Jain, M. ;
Kanthala, A. R. ;
Damania, D. ;
Stead, L. G. ;
Wang, H. Z. ;
Jahromi, B. S. .
AMERICAN JOURNAL OF NEURORADIOLOGY, 2013, 34 (10) :1895-1900
[10]   Fingolimod Reduces Hemorrhagic Transformation Associated With Delayed Tissue Plasminogen Activator Treatment in a Mouse Thromboembolic Model [J].
Campos, Francisco ;
Qin, Tao ;
Castillo, Jose ;
Seo, Ji Hae ;
Arai, Ken ;
Lo, Eng H. ;
Waeber, Christian .
STROKE, 2013, 44 (02) :505-+