快速老化模型小鼠SAMP8行为学的增龄性变化

被引：18

作者：

褚芹 ^{[1
]}

于建春 ^{[1
]}

潘建明 ^{[2
]}

于涛 ^{[1
]}

韩景献 ^{[1
]}

机构：

[1] 天津中医药大学第一附属医院

[2] 天津中医药大学解剖教研室

来源：

现代生物医学进展 | 2008年 / 10期

基金：

国家自然科学基金重点项目;

关键词：

快速老化模型小白鼠(SAM); SAMP8; 老化; Morris水迷宫; 学习记忆能力;

D O I：

10.13241/j.cnki.pmb.2008.10.021

中图分类号：

R-332 [医用实验动物学];

学科分类号：

1001 ;

摘要：

目的:对快速老化模型小白鼠SAMP8老化征象和学习记忆能力的增龄性变化进行系统研究,为利用该模型进行其它研究提供实验依据。方法:选用2、4、6、8、10、12月龄SAMP8,以同龄正常老化的SAMR1为对照,应用老化度评分和Morris水迷宫测试SAMP8的老化度和学习记忆能力的增龄性变化。结果:SAMP8在4月龄出现明显的老化体征,并在6月龄开始表现出空间学习记忆障碍。结论:SAMP8在成熟期(4-6月)过后发生了快速老化,证实SAMP8是研究衰老和老年性痴呆的理想模型。

引用

页码：1801 / 1804

页数：4

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