重复经颅磁刺激对脑梗死后轻度认知功能障碍的影响及安全性研究

被引：29

作者：

李亚梅

徐丽

杨艳

田金艳

余茜

机构：

[1] 四川省医学科学院,四川省人民医院

来源：

中国康复理论与实践 | 2015年 / 10期

关键词：

脑梗死; 轻度认知功能障碍; 重复经颅磁刺激; 事件相关电位; P300;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨重复经颅磁刺激(r TMS)对脑梗死患者轻度认知障碍的影响及安全性。方法 45例脑梗死后具有认知功能损害但未达痴呆诊断标准的患者,随机分为对照组(n=22)和观察组(n=23)。两组均予常规药物治疗和认知训练,观察组加以r TMS治疗(刺激左侧前额叶背外侧皮质,5 Hz,80%运动阈值),疗程4周。结果治疗后两组蒙特利尔认知评估量表(Mo CA)评分、事件相关电位P300的潜伏期和波幅均较治疗前显著改善(P<0.001),且观察组优于对照组(P<0.05)。观察组治疗后Mo CA得分与P300潜伏期呈高度负相关(r=-0.851,P<0.05)。治疗过程中未见明显不良反应。结论 r TMS可能对脑梗死患者的轻度认知功能障碍有改善作用,且相对安全。

引用

页码：1128 / 1132

页数：5

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