老年急性缺血性脑卒中患者血同型半胱氨酸水平与不良结局的关系

被引：11

作者：

张晓璇 ^{[1
]}

仲崇科 ^{[2
]}

曹星华 ^{[1
]}

邱海鹏 ^{[1
]}

赵亮 ^{[1
]}

李佳佳 ^{[1
]}

高燕军 ^{[1
]}

许锬 ^{[2
]}

机构：

[1] 承德医学院附属医院神经内科

[2] 苏州大学医学部公共卫生学院流行病与卫生统计学教研室

来源：

中国老年学杂志 | 2015年 / 35卷 / 10期

关键词：

血浆同型半胱氨酸; 急性缺血性脑卒中; 出院结局;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

目的探讨老年急性缺血性脑卒中患者血浆同型半胱氨酸(Hcy)水平与其出院结局不良的关系。方法采用回顾性队列研究的方法,连续性纳入急性缺血性脑卒中住院患者1 688例,收集人口统计学、生活方式和实验室检查结果等资料。结局不良定义为患者出院时改良的Rankin评分(MRS)≥3分,结局良好MRS<3分。采用非条件Logistic回归分析入院时血浆Hcy水平与出院结局不良的关系。结果结局良好组与结局不良组入院时Hcy水平差异无统计学意义(P>0.05)。用三分位数法将入院时Hcy水平分为3组,<12.5μmol/L,12.5～18.6μmol/L,>18.6μmol/L,3组的结局不良发生率分别为29.47%,34.30%,36.23%。经单因素非条件Logistic回归分析结果发现,与入院时<12.5μmol/L组相比,>18.6μmol/L组发生出院结局不良的OR值(95%CI)为1.332(1.012～1.752)。经多因素调整后,同样>18.6μmol/L组增加了急性缺血性脑卒中患者发生出院结局不良的风险,OR值(95%CI)为1.455(1.025～2.131),并且随着Hcy水平的升高发生出院结局不良的风险也在增加(趋势性P<0.05)。结论入院时血浆Hcy水平升高可增加急性缺血性脑卒中患者出院结局不良发生的风险,并存在剂量-反应关系,是独立的危险因素。

引用

页码：2660 / 2662

页数：3

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