他汀类药物,从心血管疾病到肾脏病

被引:10
作者
李振勇
倪兆慧
机构
[1] 上海交通大学医学院附属仁济医院肾脏科
关键词
他汀类药物; 心血管疾病; 慢性肾脏病;
D O I
暂无
中图分类号
R96 [药理学];
学科分类号
100602 ; 100706 ;
摘要
随着他汀类药物在临床上的广泛应用,其降脂和各种降脂外作用能在很大程度上减少心血管事件发生的风险;同时,人们也对他汀类药物在慢性肾脏疾病中的肾保护作用产生了浓厚的兴趣,开展了一系列的试验研究来揭示他汀类药物的多效性,现就此做一综述。
引用
收藏
页码:802 / 805
页数:4
相关论文
共 7 条
[1]   他汀类药物临床研究进展 [J].
张文斌 ;
宋筱筱 ;
傅国胜 ;
蔡思宇 .
心血管病学进展, 2006, (01) :79-82
[2]   Statins protect human aortic smooth muscle cells from inorganic phosphate-induced calcification by restoring Gas6-Axl survival pathway [J].
Son, BK ;
Kozaki, K ;
Iijima, K ;
Eto, M ;
Kojima, T ;
Ota, H ;
Senda, Y ;
Maemura, K ;
Nakano, T ;
Akishita, M ;
Ouchi, Y .
CIRCULATION RESEARCH, 2006, 98 (08) :1024-1031
[3]   Combined effects of losartan and pravastatin on interstitial inflammation and fibrosis in chronic cyclosporine-induced nephropathy [J].
Li, C ;
Sun, BK ;
Lim, SW ;
Song, JC ;
Kang, SW ;
Kim, YS ;
Kang, DH ;
Cha, JH ;
Kim, J ;
Yang, CW .
TRANSPLANTATION, 2005, 79 (11) :1522-1529
[4]  
Fluvastatin Enhances the Inhibitory Effects of a Selective AT1 Receptor Blocker, Valsartan, on Atherosclerosis[J] . Zhen Li,Masaru Iwai,Lan Wu,Hong-Wei Liu,Rui Chen,Toyohisa Jinno,Jun Suzuki,Masahiro Tsuda,Xin-Yu Gao,Midori Okumura,Tai-Xing Cui,Masatsugu Horiuchi.Hypertension . 2004 (5)
[5]   Statins inhibit in vitro calcification of human vascular smooth muscle cells induced by inflammatory mediators [J].
Kizu, A ;
Shioi, A ;
Jono, S ;
Koyama, H ;
Okuno, Y ;
Nishizawa, Y .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 93 (05) :1011-1019
[6]   Lovastatin reduces glomerular macrophage influx and expression of monocyte chemoattractant protein-1 mRNA in nephrotic rats [J].
Park, YS ;
Guijarro, C ;
Kim, Y ;
Massy, ZA ;
Kasiske, BL ;
Keane, WF ;
O'Donnell, MP .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1998, 31 (01) :190-194
[7]   Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors [J].
Laufs, U ;
La Fata, V ;
Plutzky, J ;
Liao, JK .
CIRCULATION, 1998, 97 (12) :1129-1135