脑缺血后神经血管保护机制和损伤机制研究进展

被引：25

作者：

陆征宇 ^{[1
,2
]}

董强 ^{[1
]}

机构：

[1] 复旦大学附属华山医院神经内科

[2] 中医药大学附属岳阳中西医结合医院神经内科

来源：

中华脑血管病杂志(电子版) | 2013年 / 7卷 / 03期

关键词：

卒中; 脑缺血; 神经保护; 脑损伤; 神经血管单元;

D O I：

暂无

中图分类号：

R743 [脑血管疾病];

学科分类号：

1002 ;

摘要：

脑梗死是致死性疾病之一,发病率高,严重危害人类健康。尽管各方面的研究不断深入,但是目前仍然缺乏有效的神经保护药物,脑梗死的治疗依然是一个非常棘手的问题。本文从内源性保护机制、谷氨酸受体的双向作用、非谷氨酸依赖的钙失衡损伤机制进行综述,进一步阐释脑缺血后神经血管的保护机制和损伤机制,以求突破神经保护研究的传统框架,寻找神经血管保护

引用

页码：34 / 40

页数：7

共 85 条

[1]

Vascular protection by angiotensin receptor antagonism involves differential VEGF expression in both hemispheres after experimental stroke..[J].Weihua Guan;Payaningal R Somanath;Anna Kozak;Anna Goc;Azza B El-Remessy;Adviye Ergul;Maribeth H Johnson;Ahmed Alhusban;Sahar Soliman;Susan C Fagan.PLoS ONE.2017, 9

[2] HIF-1 and c-Src Mediate Increased Glucose Uptake Induced by Endothelin-1 and Connexin43 in Astrocytes [J].

Carlos Valle-Casuso, Jose ;

Gonzalez-Sanchez, Ana ;

Medina, Jose M. ;

Tabernero, Arantxa .

PLOS ONE, 2012, 7 (02)

[3] Heat shock protein 72 inhibits c-Jun N-terminal kinase 3 signaling pathway via Akt1 during cerebral ischemia [J].

Qi, Dashi ;

Liu, Hongzhi ;

Niu, Jian ;

Fan, Xing ;

Wen, Xiangru ;

Du, Yang ;

Mou, Jie ;

Pei, Dongsheng ;

Liu, Zhian ;

Zong, Zhimin ;

Wei, Xianyong ;

Song, Yuanjian .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 317 (1-2) :123-129

[4]

Hypoxia induces angiogenic factors in brain microvascular endothelial cells.[J].J. Luo;J. Martinez;X. Yin;A. Sanchez;D. Tripathy;P. Grammas.Microvascular Research.2011, 2

[5]

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons.[J]..Experimental Neurology.2011, 1

[6] Executive Summary: Heart Disease and Stroke Statistics-2012 Update A Report From the American Heart Association [J].

Roger, Veronique L. ;

Go, Alan S. ;

Lloyd-Jones, Donald M. ;

Benjamin, Emelia J. ;

Berry, Jarett D. ;

Borden, William B. ;

Bravata, Dawn M. ;

Dai, Shifan ;

Ford, Earl S. ;

Fox, Caroline S. ;

Fullerton, Heather J. ;

Gillespie, Cathleen ;

Hailpern, Susan M. ;

Heit, John A. ;

Howard, Virginia J. ;

Kissela, Brett M. ;

Kittner, Steven J. ;

Lackland, Daniel T. ;

Lichtman, Judith H. ;

Lisabeth, Lynda D. ;

Makuc, Diane M. ;

Marcus, Gregory M. ;

Marelli, Ariane ;

Matchar, David B. ;

Moy, Claudia S. ;

Mozaffarian, Dariush ;

Mussolino, Michael E. ;

Nichol, Graham ;

Paynter, Nina P. ;

Soliman, Elsayed Z. ;

Sorlie, Paul D. ;

Sotoodehnia, Nona ;

Turan, Tanya N. ;

Virani, Salim S. ;

Wong, Nathan D. ;

Woo, Daniel ;

Turner, Melanie B. .

CIRCULATION, 2012, 125 (01) :188-197

[7] Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke [J].

Jia, Jia ;

Verma, Saurabh ;

Nakayama, Shin ;

Quillinan, Nidia ;

Grafe, Marjorie R. ;

Hurn, Patricia D. ;

Herson, Paco S. .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (11) :2160-2168

[8] Stroke research at a crossroad: asking the brain for directions [J].

Iadecola, Costantino ;

Anrather, Josef .

NATURE NEUROSCIENCE, 2011, 14 (11) :1363-1368

[9] Emerging mechanisms of disrupted cellular signaling in brain ischemia [J].

Tymianski, Michael .

NATURE NEUROSCIENCE, 2011, 14 (11) :1369-1373

[10] Exercise Improves Recovery after Ischemic Brain Injury by Inducing the Expression of Angiopoietin-1 and Tie-2 in Rats [J].

Zheng, Qingping ;

Zhu, Danian ;

Bai, Yulong ;

Wu, Yi ;

Jia, Jie ;

Hu, Yongshan .

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 224 (03) :221-228

← 1 2 3 4 5 6 7 8 9 →