恶性淋巴瘤血栓形成的研究进展

被引：12

作者：

刘鹏飞

李亚妮

王华庆

机构：

[1] 天津医科大学肿瘤医院淋巴瘤科,国家肿瘤临床医学研究中心,中美淋巴血液肿瘤诊治中心,天津市肿瘤防治重点实验室

来源：

中国肿瘤临床 | 2014年 / 06期

关键词：

静脉血栓栓塞; 恶性淋巴瘤; 预防; 治疗;

D O I：

暂无

中图分类号：

R733.1 [网状内皮系统肿瘤];

学科分类号：

100214 ;

摘要：

静脉血栓栓塞(venous thrombolism,VTE)是恶性肿瘤患者第二致死原因,并且癌症患者是血栓栓塞的高发人群,其预防和治疗是非常重要的。肿瘤患者发生VTE的风险较非肿瘤患者至少增加7倍,而血液系统肿瘤并发VTE的概率则较非肿瘤患者增加28倍,严重影响了恶性淋巴瘤患者的预后和生活质量。恶性淋巴瘤患者并发VTE的机制和危险因素尚未明确,VTE的发生与组织因子、微粒以及基因的单核苷酸多态性相关。为了降低VTE发生率,预测可能发生VTE的高危患者是非常重要的,这些患者将会从血栓预防中受益,因此临床上急需一种简单有效的VTE风险评估模型,联合检测外周血中生物标记物可提高VTE诊断率。由于淋巴瘤患者发生出血的风险较高,导致血栓的治疗更加复杂。本文就恶性淋巴瘤患者发生VTE的流行病学、发病机制、预防和治疗的最新研究做一综述。

引用

页码：408 / 410

页数：3

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