脂联素基因多态性(-11377C/G,-3964A/G,-45T/G)与脑梗死相关性研究

被引：7

作者：

相波 ^{[1
]}

丁晓洁 ^{[2
]}

张磊 ^{[3
]}

王超 ^{[1
]}

王晓青 ^{[1
]}

潘旭东 ^{[4
]}

机构：

[1] 青岛大学医学院第二附属医院神经内科

[2] 青岛大学医学院第二附属医院高压氧科

[3] 青岛大学医学院第二附属医院检验科

[4] 青岛大学医学院第一附属医院东院神经内科

来源：

中风与神经疾病杂志 | 2014年 / 31卷 / 02期

关键词：

脑梗死; 脂联素; 基因多态性; 单倍型;

D O I：

10.19845/j.cnki.zfysjjbzz.2014.02.008

中图分类号：

R743.33 [脑栓塞];

学科分类号：

1002 ;

摘要：

目的探讨青岛地区汉族人群脂联素(adiponectin,ADIPOQ)基因多态性与脑梗死的相关性。方法病例对照研究,选取372例急性脑梗死患者(发病≤3 d)和416例同期查体者。采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction-restriction fragment lengyh polymorphism,PCR-RFLP)或直接测序法检测ADIPOQ基因多态性。应用多因素logistic回归分析研究基因多态性与脑梗死的相关性。结果 rs266729(-11377 C/G)的基因型分布在脑梗死组和对照组中有统计学差异(P<0.05);在显性、隐性和累加模式下,rs266729的基因型分布在两组中也有统计学差异(P<0.05),rs266729的G等位基因变异能增加脑梗死的易感性(3种模式下OR值分别为:1.35、2.15、2.33)。调整脑梗死各危险因素后,多因素logistic回归分析表明显性模式下rs266729仍与脑梗死易感性相关(P=0.049,OR=1.44)。rs822396(-3964A/G)和rs2241766(-45T/G)的基因型分布在两组中无统计学差异(P>0.05)。单倍型分析显示脑梗死组和对照组无统计学差异。结论 rs266729(-11377 C/G)基因多态性与脑梗死的易感性相关;rs266729的G等位基因变异可能是脑梗死易感性的危险因素。

引用

页码：125 / 129

页数：5

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