钙超载的危害和新型钙阻断剂的研发

被引:13
作者
薛全福 [1 ]
王振纲 [2 ]
机构
[1] 中国医学科学院-北京协和医学院基础学院生理和病理生理学系
[2] 中国医学科学院-北京协和医学院基础学院药理学系
关键词
钙超载; 疾病; 钙阻断剂;
D O I
暂无
中图分类号
R966 [分子药理学];
学科分类号
100602 ; 100706 ;
摘要
目的介绍细胞钙超载的危害及新型钙阻断剂的研发和应用。方法对近期文献进行综述。结果细胞内钙超载对人体有害,可导致高血压,神经元损伤(包括癫痫、偏头痛、慢性神经性头痛、阿尔茨海默病),胰腺炎,细胞凋亡,缺血再灌注损伤等,已分别研发出新型的钙阻断剂,包括同时作用于L及T型钙通道的阻断剂,作用于钙通道α2δ亚基的阻断剂,作用于胞内IP3受体的阻断剂,同时作用于钙通道及钙调蛋白的阻断剂等且取得疗效。结论在我国应加强研究钙超载的危害及新型钙阻断剂的研发会给药物分子治疗学增添新的亮点。
引用
收藏
页码:150 / 152
页数:3
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