阿替普酶静脉溶栓后发生早期神经功能恶化的研究进展

被引：20

作者：

崔颖 ^{[1
,2
]}

佟旭 ^{[2
,3
]}

王伊龙 ^{[3
]}

郑华光 ^{[3
]}

曹亦宾 ^{[2
]}

机构：

[1] 华北理工大学研究生院

[2] 华北理工大学附属唐山市工人医院神经内科

[3] 首都医科大学附属北京天坛医院卒中临床试验与临床研究中心

来源：

中国卒中杂志 | 2017年 / 02期

关键词：

急性缺血性卒中; 阿替普酶; 静脉溶栓; 早期神经功能恶化; 病因; 危险因素;

D O I：

暂无

中图分类号：

R743.3 [急性脑血管疾病（中风）];

学科分类号：

1002 ;

摘要：

尽管多数急性缺血性卒中患者经阿替普酶静脉溶栓治疗后症状有所缓解,仍有相当一部分患者经历早期神经功能恶化(early neurological deterioration,END),症状进一步加重。目前学术界对于END的定义尚未统一,因此导致END的发生率不尽相同。关于END确切病因、危险因素以及相关病理生理机制仍是学术界讨论的热点。END的发生强烈提示患者3个月预后不良。本文就以上内容进行综述。

引用

页码：192 / 198

页数：7

共 33 条

[1] 第三次全国死因调查主要情况 [J].

中国肿瘤, 2008, (05) :344-345

[2]

Repeated Intravenous Thrombolysis for Early Recurrent Stroke: Challenging the Exclusion Criterion[J] . Timo Kahles,Marie-Luise Mono,Mirjam Rachel Heldner,Ralf Werner Baumgartner,Hakan Sarikaya,Andreas Luft,Stephan Bohlhalter,Christopher Traenka,Stefan T. Engelter,Natalia Kurka,Martin K?hrmann,Sami Curtze,Patrik Michel,Turgut Tatlisumak,Krassen Nedeltchev.Stroke . 2016 (8)

[3] Outcome of intravenous recombinant tissue plasminogen activator for acute ischemic stroke in patients aged over 80 years [J].

Mione, Gioia ;

Ducrocq, Xavier ;

Thilly, Nathalie ;

Lacour, Jean-Christophe ;

Vespignani, Herve ;

Richard, Sebastien .

GERIATRICS & GERONTOLOGY INTERNATIONAL, 2016, 16 (07) :843-849

[4]

Intravenous thrombolysis for acute ischaemic stroke in the elderly: data from the B aden‐ W uerttemberg stroke registry[J] . B. Reuter,C. Gumbinger,T. Sauer,H. Wieth?lter,I. Bruder,S. Rode,P. A. Ringleb,R. Kern,W. Hacke,M. G. Hennerici.Eur J Neurol . 2016 (1)

[5]

The Etiologies of Early Neurological Deterioration after Thrombolysis and Risk Factors of Ischemia Progression[J] . Jeong-Min Kim,Jangsup Moon,Suk-Won Ahn,Hae-Won Shin,Keun-Hwa Jung,Kwang-Yeol Park.Journal of Stroke and Cerebrovascular Diseases . 2015

[6] Timing of recanalization and outcome in ischemic-stroke patients treated with recombinant tissue plasminogen activator [J].

Wei, Xiao-Er ;

Zhao, Yu-Wu ;

Lu, Jing ;

Li, Ming-Hua ;

Li, Wen-Bin ;

Zhou, Ya-Jun ;

Li, Yue-Hua .

ACTA RADIOLOGICA, 2015, 56 (09) :1119-1126

[7]

Recurrent ischemic stroke can happen in stroke patients very early after intravenous thrombolysis[J] . Haris Kamal,Ashkan Mowla,Salman Farooq,Peyman Shirani.Journal of the Neurological Sciences . 2015 (1-2)

[8]

Pre-existing Mobile Cardiac Thrombus and the Risk of Early Recurrent Embolism after Intravenous Thrombolysis: A Case Report[J] . Manami Kobayashi,Ryota Tanaka,Kazuo Yamashiro,Yuji Ueno,Etsuro Kato,Seiji Miura,Hiroyuki Daida,Nobutaka Hattori.Journal of Stroke and Cerebrovascular Diseases . 2015 (6)

[9] Brain Edema Predicts Outcome After Nonlacunar Ischemic Stroke [J].

Battey, Thomas W. K. ;

Karki, Mahima ;

Singhal, Aneesh B. ;

Wu, Ona ;

Sadaghiani, Saloomeh ;

Campbell, Bruce C. V. ;

Davis, Stephen M. ;

Donnan, Geoffrey A. ;

Sheth, Kevin N. ;

Kimberly, W. Taylor .

STROKE, 2014, 45 (12) :3643-+

[10] Mechanisms of Unexplained Neurological Deterioration After Intravenous Thrombolysis [J].

Tisserand, Marie ;

Seners, Pierre ;

Turc, Guillaume ;

Legrand, Laurence ;

Labeyrie, Marc-Antoine ;

Charron, Sylvain ;

Meder, Jean-Francois ;

Mas, Jean-Louis ;

Oppenheim, Catherine ;

Baron, Jean-Claude .

STROKE, 2014, 45 (12) :3527-+

← 1 2 3 4 →