辛伐他汀的药物基因组学研究进展

被引：2

作者：

付秀敏 ^{[1
]}

叶丽卡 ^{[2
]}

机构：

[1] 总参谋部通信部沈阳离职干部休养所

[2] 广州医学院第二附属医院

来源：

今日药学 | 2009年 / 19卷 / 06期

关键词：

辛伐他汀; 降脂疗效; 调脂疗效; CYP; 辛伐他丁; 降血脂药; 胆固醇酯转运蛋白基因; 基因多态性; 遗传多态性; 药物; 基因组学;

D O I：

暂无

中图分类号：

R96 [药理学];

学科分类号：

100602 ; 100706 ;

摘要：

引用

收藏

页码：13 / 16

页数：4

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[1] HMG-CoA还原酶基因多态性对辛伐他汀调脂疗效的影响 [J].

苏颖 ;

孙延明 ;

刘晓民 ;

栾颖 ;

王月影 .

中国老年学杂志, 2008, (04) :362-364

[2] 胆固醇酯转运蛋白基因I405V多态性与辛伐他汀的调脂效应 [J].

刘晋秦 ;

祖凌云 ;

赵春玉 ;

薛琳 ;

张岩 ;

李建平 ;

高炜 .

中国临床康复, 2005, (31) :102-104

[3] 胆固醇酯转移蛋白Taq IB基因多态性与辛伐他汀调脂疗效的相关性 [J].

朱燕林 ;

严晓伟 ;

鄢盛恺 ;

朱文玲 .

中国临床药理学杂志, 2004, (03) :183-185

[4] THE INFLUENCE OF APOLIPOPROTEIN B AND E GENE POLYMORPHISMS ON THE RESPONSE TO SIMVASTATIN THERAPY IN PATIENTS WITH HYPERLIPIDEMIA [J].

叶平 ;

尚延忠 ;

丁小平 .

Chinese Medical Sciences Journal, 2003, (01) :9-13

[5] Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme a reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin [J].

Medina, Marisa Wong ;

Gao, Feng ;

Ruan, Weiming ;

Rotter, Jerome I. ;

Krauss, Ronald M. .

CIRCULATION, 2008, 118 (04) :355-362

[6] CYP3A4*1G polymorphism is associated with lipid-lowering efficacy of atorvastatin but not of simvastatin [J].

Gao, Yuan ;

Zhang, Li-rong ;

Fu, Qiang .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 64 (09) :877-882

[7] Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment [J].

Krauss, Ronald M. ;

Mangravite, Lara M. ;

Smith, Joshua D. ;

Medina, Marisa W. ;

Wang, Dai ;

Guo, Xiuqing ;

Rieder, Mark J. ;

Simon, Joel A. ;

Hulley, Steven B. ;

Waters, David ;

Saad, Mohammed ;

Williams, Paul T. ;

Taylor, Kent D. ;

Yang, Huiying ;

Nickerson, Deborah A. ;

Rotter, Jerome I. .

CIRCULATION, 2008, 117 (12) :1537-1544

[8] Pharmacogenetic study of cholesteryl ester transfer protein gene and simvastatin treatment in hypercholesterolaemic subjects [J].

Anagnostopoulou, Katherine ;

Kolovou, Genovefa ;

Kostakou, Peggy ;

Mihas, Constantinos ;

Mikhailidis, Dimitri ;

Cokkinos, Dennis V. .

EXPERT OPINION ON PHARMACOTHERAPY, 2007, 8 (15) :2459-2463

[9] Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients [J].

Wang, A ;

Yu, BN ;

Luo, CH ;

Tan, ZR ;

Zhou, G ;

Wang, LS ;

Zhang, W ;

Li, Z ;

Liu, J ;

Zhou, HH .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 60 (12) :843-848

[10] Association of TaqIB polymorphism in the cholesteryl ester transfer protein gene with plasma lipid levels in a healthy Spanish population [J].

Corella, D ;

Sáiz, C ;

Guillén, M ;

Portolés, O ;

Mulet, F ;

González, JI ;

Ordovás, JM .

ATHEROSCLEROSIS, 2000, 152 (02) :367-376