不同病因急性缺血性脑卒中患者血清S100A12水平变化及意义

被引：1

作者：

黄石仁

张永巍

邓本强

机构：

[1] 第二军医大学附属长海医院

来源：

山东医药 | 2015年 / 55卷 / 08期

关键词：

急性缺血性脑卒中; 动脉粥样硬化; S100A12; C反应蛋白;

D O I：

暂无

中图分类号：

R743.31 [短暂性脑缺血];

学科分类号：

1002 ;

摘要：

目的观察不同病因导致的急性缺血性脑卒中(CIS)患者血清钙结合蛋白S100A12水平变化,并探讨其临床意义。方法将74例CIS患者根据病因分为大动脉粥样硬化31例(LAA组)、小动脉闭塞21例(SAO组)、心主动脉栓塞12例(CAE组),选择年龄、性别相匹配的单纯颈动脉狭窄患者12例(CAS组)及同期健康体检者10例(对照组)。采用ELISA法检测各组血清S100A12和超敏C反应蛋白(hs-CRP),美国国立卫生研究院卒中量表(NIHSS)评估神经功能。结果血清S100A12、hs-CRP比较,LAA组>SAO组>CAE组、CAS组>对照组,P均<0.05。NIHSS评分比较,LAA组、SAO组>CAE组>CAS组、对照组,P均<0.05。LAA组和SAO组血清S100A12与hs-CRP均呈正相关(r分别为0.849、0.878,P均<0.01),与NIHSS评分均呈正相关(r分别为0.763、0.641,P均<0.01)。结论大动脉粥样硬化所致CIS患者血清S100A12水平升高最明显,与炎性反应的发生和神经功能缺损有关。

引用

页码：58 / 59

页数：2

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