心肌营养素-1在心脏发育和心脏病发生中的作用

被引：3

作者：

吕丹

张连峰

机构：

[1] 中国医学科学院北京协和医学院实验动物研究所比较医学中心

来源：

中国分子心脏病学杂志 | 2008年 / 01期

关键词：

心肌营养素-1; 心肌病; 心衰; 心室重塑; 高血压;

D O I：

10.16563/j.cnki.1671-6272.2008.01.008

中图分类号：

R541 [心脏疾病];

学科分类号：

1002 ; 100201 ;

摘要：

心肌营养素-1是1995年Pennica等从小鼠心脏发育的胚胎干细胞中克隆表达出的一种蛋白质因子。其为白细胞介素-6细胞因子家族的新成员,它可促使心肌细胞肥大,同时也有促使心肌细胞存活的作用。在缺血性心脏病、心肌病及心力衰竭等疾病时CT-1水平均有升高。本文就CT-1在心血管领域的作用及其机理的研究进展作一综述。

引用

页码：55 / 59

页数：5

共 12 条

[1]

Cardiotrophin-1 Stimulation of Cardiac Fibroblast Growth: Roles for Glycoprotein 130/Leukemia Inhibitory Factor Receptor and the Endothelin Type A Receptor[J] . Toshihiro Tsuruda,Michihisa Jougasaki,Guido Boerrigter,Brenda K. Huntley,Horng H. Chen,Antonino B. D’Assoro,Shang C. Lee,Amy M. Larsen,Alessandro Cataliotti,John C. Burnett.Circulation Research: Journal of the American Heart Association . 2002 (2)

[2] Heat shock protein-56 is induced by cardiotrophin-1 and mediates its hypertrophic effect [J].

Railson, JE ;

Lawrence, K ;

Buddle, JC ;

Pennica, D ;

Latchman, DS .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (06) :1209-1221

[3] Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy [J].

Tsutamoto, T ;

Wada, A ;

Maeda, K ;

Mabuchi, N ;

Hayashi, M ;

Tsutsui, T ;

Ohnishi, M ;

Fujii, M ;

Matsumoto, T ;

Yamamoto, T ;

Wang, XW ;

Asai, S ;

Tsuji, T ;

Tanaka, H ;

Saito, Y ;

Kuwahara, K ;

Nakao, K ;

Kinoshita, M .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (05) :1485-1490

[4]

Augmented Expression of Cardiotrophin-1 and its Receptor Component, gp130, in both Left and Right Ventricles after Myocardial Infarction in the Rat[J] . Takeshi Aoyama,Yoshihito Takimoto,Diane Pennica,Reiko Inoue,Eiji Shinoda,Ryuichi Hattori,Yoshiki Yui,Shigetake Sasayama.Journal of Molecular and Cellular Cardiology . 2000 (10)

[5]

Isolation and Characterization of the Murine Cardiotrophin-1 Gene: Expression and Norepinephrine-Induced Transcriptional Activation[J] . Masanobu Funamoto,Shigemichi Hishinuma,Yasushi Fujio,Yoichi Matsuda,Keita Kunisada,Hidemasa Oh,Shinji Negoro,Eiroh Tone,Tadamitsu Kishimoto,Keiko Yamauchi-Takihara.Journal of Molecular and Cellular Cardiology . 2000 (7)

[6]

Cardiotrophin-1 Phosphorylates Akt and BAD, and Prolongs Cell Survival via a PI3K-dependent Pathway in Cardiac Myocytes[J] . Koichiro Kuwahara,Yoshihiko Saito,Ichiro Kishimoto,Yoshihiro Miyamoto,Masaki Harada,Emiko Ogawa,Ichiro Hamanaka,Noboru Kajiyama,Nobuki Takahashi,Takehiko Izumi,Rika Kawakami,Kazuwa Nakao.Journal of Molecular and Cellular Cardiology . 2000 (8)

[7] Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro [J].

Kuwahara, K ;

Saito, Y ;

Harada, M ;

Ishikawa, M ;

Ogawa, E ;

Miyamoto, Y ;

Hamanaka, I ;

Kamitani, S ;

Kajiyama, N ;

Takahashi, N ;

Nakagawa, O ;

Masuda, I ;

Nakao, K .

CIRCULATION, 1999, 100 (10) :1116-1124

[8] A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats [J].

Ishikawa, M ;

Saito, Y ;

Miyamoto, Y ;

Harada, M ;

Kuwahara, K ;

Ogawa, E ;

Nakagawa, O ;

Hamanaka, I ;

Kajiyama, N ;

Takahashi, N ;

Masuda, I ;

Hashimoto, T ;

Sakai, O ;

Hosoya, T ;

Nakao, K .

JOURNAL OF HYPERTENSION, 1999, 17 (06) :807-816

[9] Cytokines and cardiomyocyte death [J].

Pulkki, KJ .

ANNALS OF MEDICINE, 1997, 29 (04) :339-343

[10] In vivo effects of cardiotrophin-1 [J].

Jin, HK ;

Yang, RH ;

Keller, GA ;

Ryan, A ;

Ko, A ;

Finkle, D ;

Swanson, TA ;

Li, W ;

Pennica, D ;

Wood, WI ;

Paoni, NF .

CYTOKINE, 1996, 8 (12) :920-926

← 1 2 →