MTHFR基因C677T多态性与汉族人群抑郁症的关联性

被引：5

作者：

李则挚 ^{[1
]}

禹顺英 ^{[2
]}

张晨 ^{[1
]}

苑成梅 ^{[1
]}

洪武 ^{[1
]}

王勇 ^{[1
]}

陈俊 ^{[1
]}

黄佳 ^{[1
]}

汪栋祥 ^{[2
]}

方贻儒 ^{[1
]}

机构：

[1] 上海交通大学医学院附属精神卫生中心心境障碍科

[2] 上海交通大学医学院附属精神卫生中心遗传研究室

来源：

上海交通大学学报(医学版) | 2010年 / 30卷 / 06期

基金：

国家科技攻关计划;

关键词：

抑郁症; N5,N10-亚甲基四氢叶酸还原酶; 基因多态性;

D O I：

暂无

中图分类号：

R749.41 [];

学科分类号：

100205 ;

摘要：

目的探讨N5,N10_亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与汉族人群抑郁症发生的关系。方法纳入符合美国精神障碍诊断与统计手册第4版(DSM-IV)诊断标准的抑郁症患者402例和正常对照者600名,均为汉族。入组时对抑郁症患者进行汉密尔顿抑郁量表(HAMD)-17评定,采用PCR-RFLP技术检测MTHFR基因C677T的多态性。结果抑郁症组与对照组基因型(CC、CT、TT)分布频率差异均有统计学意义(P<0.05);其中抑郁症组TT基因型频率显著高于正常对照组,差异有统计学意义(P<0.05)。抑郁症组CT和TT基因型患者的HAMD-17评分均显著高于CC型,差异有统计学意义(P<0.05)。结论 MTHFR基因C677T多态性与抑郁症关联,且TT基因型与抑郁症的严重程度相关。

引用

页码：624 / 627

页数：4

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