炎症可能是联接高血压和动脉粥样硬化的桥梁

被引:28
作者
李建军
机构
[1] 中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院冠心病诊疗中心北京市
关键词
动脉粥样硬化; 炎症机制; 冠心病; 血管紧张素; 内皮素; 危险因子; 动脉硬化; 冠状动脉病; 血管紧张肽; 寡肽; 高血压; 高血压病患者;
D O I
10.16563/j.cnki.1671-6272.2005.01.001
中图分类号
R544.1 [高血压]; R543 [血管疾病];
学科分类号
1002 ; 100201 ;
摘要
<正>动脉粥样硬化形成机制被认为是多因素参与,以慢性炎症反应为特征。众所周知,高血压是动脉粥样硬化最重要的危险因子之一,但人们对高血压导致早期动脉粥样硬化的机制仍认识不足。越来越多的证据表明:高血压时,血管活性肽如血管紧张素和内皮素-1,通过炎症机制促进和加速动脉粥样硬化过程。人体和动物实验研究表明,在心脏和肾脏传输血管和小动脉,血管紧张素Ⅱ都显
引用
收藏
页码:385 / 388
页数:4
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共 31 条
[1]  
Schmid-Schonbein GW,Seiffge D,Delano FA,et al.Leukocyte counts and activation in spontaneously hypertensive and normotensive rats. Journal of Hypertension . 1991
[2]  
Dorffel Y,Latsch C,Stuhlmuller B,et al.Preactivation peripheral blood monocytes in patients with essential hypertension. Journal of Hypertension . 1999
[3]  
Li J-J,Chen X-J.Simvastatin inhibits interleukin-6 release in human monocytes stimulated by C-reactive protein as well as lipopo-lysaccharide. Coronary Artery Disease . 2003
[4]  
Haller H,Behrend M,Park JK,et al.Monocyte infiltration and c-fms expression in hearts of spontaneously hypertensive rats. Journal of Hypertension . 1995
[5]  
Li J-J,Fang C-H.Atheroscleritis is a more rational term for the pathological entity currently known as atherosclerosis. Medical Hypotheses . 2004
[6]  
Nickenig G.Central role of the AT1-receptor in atherosclerosis. Journal of Human Hypertension . 2002
[7]  
Li J-J.C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular disease. Medical Hypotheses . 2004
[8]  
Grundy SM.Inflammation, hypertension, and the metabolic syndrome. The Journal of The American Medical Association . 2003
[9]  
Hilgers KF,Hartner A,Porst M,et al.Monocyte chemoattractant protein-1 and macrophage infiltration in hypertensive kidney injury. Kidney International . 2000
[10]  
Sesso HD,Buring JE,Rifai N,et al.C-reactive protein and the risk of developing hypertension. The Journal of The American Medical Association . 2003