The kallikrein-kinin system: a promising therapeutic target for traumatic brain injury

被引：3

作者：

Sarah Hopp

Christiane Albert-Weissenberger

机构：

[1] DepartmentofNeurology,UniversityHospitalWürzburg

来源：

NeuralRegenerationResearch | 2015年 / 10卷 / 06期

关键词：

TBI; a promising therapeutic target for traumatic brain injury; The kallikrein-kinin system;

D O I：

暂无

中图分类号：

R651.15 [];

学科分类号：

1002 ; 100210 ;

摘要：

<正>Traumatic brain injury(TBI),which results from an outside force causing mechanical disruption of brain tissue,is potentially life-threatening and therefore a critical public health problem throughout the world.In the USA,approximately 1.7 million individuals per year sustain a TBI,and about 43%of patients hospitalized because of TBI develop long-term physical disability as well as psychological disorders,such as neurocognitive deficits,epilepsy,and depression(Roozenbeek et al.,2013).The primary brain damage

引用

页码：885 / 886

页数：2

共 10 条

[1] Kallikrein-Kinin System Mediated Inflammation in Alzheimer's Disease In Vivo [J].

Viel, T. A. ;

Buck, H. S. .

CURRENT ALZHEIMER RESEARCH, 2011, 8 (01) :59-66

[2]

Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood–brain barrier leakage and inflammation. Furat Raslan,Tobias Schwarz,Sven G Meuth,Madeleine Austinat,Michael Bader,Thomas Renné,Klaus Roosen,Guido Stoll,Anna-Leena Sirén,Christoph Kleinschnitz. Journal of Cerebral Blood Flow & Metabolism . 2010

[3]

The role of bradykinin B-1 and B-2 receptors for secondary brain damage after traumatic brain injury in mice. Raimund Trabold,Christian Eroes,Klaus Zweckberger. Journal of Cerebral Blood Flow and Metabolism . 2010

[4]

Ischemic stroke and traumatic brain injury: The role of the kallikrein–kinin system[J] . &nbspProgress in Neurobiology . 2012

[5]

C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation. ALBERT-WEISSENBERGER C,MENCL C,SCHUHMANN MK,et al. Front Cell Neurosci . 2014

[6] What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders? [J].

Maria da Graa Naffah-Mazzacoratti ;

Telma Luciana Furtado Gouveia ;

Priscila Santos Rodrigues Simōes ;

Sandra Regina Perosa .

World Journal of Biological Chemistry, 2014, (02) :130-140

[7]

Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. Christiane Albert-Weissenberger,Christian Stetter,Sven G. Meuth. Journal of Cerebral Blood Flow and Metabolism . 2012

[8]

Role of kinin B1 and B2 receptors in memory consolidation during the aging process of mice[J] . &nbspNeuropeptides . 2009 (2)

[9]

Changing patterns in the epidemiology of traumatic brain injury. Roozenbeek B,Maas AI,Menon DK. Nat Rev Neurol . 2013

[10]

Cognitiveand cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’’s disease mice. Lacoste B,Tong XK,Lahjouji K,Couture R,Hamel E. J Neuroinflammation . 2013

← 1 →