ENDOCYTOSIS OF FORMALDEHYDE-TREATED SERUM-ALBUMIN VIA SCAVENGER PATHWAY IN LIVER ENDOTHELIAL-CELLS

被引：111

作者：

BLOMHOFF, R ^{[1
]}

ESKILD, W ^{[1
]}

BERG, T ^{[1
]}

机构：

[1] UNIV OSLO, SCH MED, INST NUTR RES, OSLO, NORWAY

来源：

BIOCHEMICAL JOURNAL | 1984年 / 218卷 / 01期

关键词：

D O I：

10.1042/bj2180081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Denatured or modified proteins (including albumin and low-density lipoprotein) are catabolized in vitro via scavenger receptors. The distribution of formaldehyde-denatured albumin was studied in rat liver cells after i.v. injection of tracer doses of the protein. At 12 min after injection, most of the formaldehyde-denatured albumin (.apprx. 70% of the injected dose) was recovered in liver endothelial cells. Furthermore, isolated liver endothelial cells in suspension and in surface culture took up formaldehyde-denatured albumin by receptor-mediated endocytosis. The scavenger receptor in liver is mainly located on the endothelial cells. Implications for the catabolism of low-density lipoproteins are discussed.

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页码：81 / 86

页数：6

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