生长分化因子15与心血管疾病——从基础到临床

被引：2

作者：

顾宇英

张代富

机构：

[1] 同济大学附属东方医院心内科

来源：

第二军医大学学报 | 2010年 / 31卷 / 03期

关键词：

生长分化因子15; 转化生长因子β; 心血管疾病;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

1002 ; 100201 ;

摘要：

生长分化因子-15(growth differentiation factor-15,GDF-15)是转化生长因子β(transforming growth factorβ,TGF-β)超家族成员的一个远支,是一个重要的心血管保护因子。作为新的标志物,GDF-15水平与多种心血管疾病的诊断、危险分层和预后判断有密切关系。本文就GDF-15基因的生物学特点及其在心血管疾病中的多种功能作一综述。

引用

页码：317 / 320

页数：4

共 11 条

[1]

Growth Differentiation Factor-15: a New Biomarker in Cardiovascular Disease[J] . Tibor Kempf,Kai C. Wollert.Herz . 2009 (8)

[2]

Growth-Differentiation Factor-15 for Risk Stratification in Patients With Stable and Unstable Coronary Heart Disease: Results From the AtheroGene Study[J] . Tibor Kempf,Jan-Malte Sinning,Anja Quint,Christoph Bickel,Christoph Sinning,Philipp S. Wild,Renate Schnabel,Edith Lubos,Hans J. Rupprecht,Thomas Münzel,Helmut Drexler,Stefan Blankenberg,Kai C. Wollert.Circulation: Cardiovascular Genetics . 2009 (3)

[3]

Growth Differentiation Factor 15 for Risk Stratification and Selection of an Invasive Treatment Strategy in Non–ST-Elevation Acute Coronary Syndrome[J] . Kai C. Wollert,Tibor Kempf,Bo Lagerqvist,Bertil Lindahl,Sylvia Olofsson,Tim Allhoff,Timo Peter,Agneta Siegbahn,Per Venge,Helmut Drexler,Lars Wallentin.Circulation . 2007 (14)

[4] Prognostic utility of growth differentiation factor-15 in patients with chronic heart failure [J].

Kempf, Tibor ;

von Haehling, Stephan ;

Peter, Timo ;

Allhoff, Tim ;

Cicoira, Mariantonietta ;

Doehner, Wolfram ;

Ponikowski, Piotr ;

Filippatos, Gerasimos S. ;

Rozentryt, Plotr ;

Drexler, Helmut ;

Anker, Stefan D. ;

Wollert, Kai C. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (11) :1054-1060

[5]

Prognostic Value of Growth-Differentiation Factor-15 in Patients With Non–ST-Elevation Acute Coronary Syndrome[J] . Kai C. Wollert,Tibor Kempf,Timo Peter,Sylvia Olofsson,Stefan James,Nina Johnston,Bertil Lindahl,Rüdiger Horn-Wichmann,Georg Brabant,Maarten L. Simoons,Paul W. Armstrong,Robert M. Califf,Helmut Drexler,Lars Wallentin.Circulation . 2007 (8)

[6] The transforming growth factor-β superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury [J].

Kempf, T ;

Eden, M ;

Strelau, J ;

Naguib, M ;

Willenbockel, C ;

Tongers, J ;

Heineke, J ;

Kotlarz, D ;

Xu, J ;

Molkentin, JD ;

Niessen, HW ;

Drexler, H ;

Wollert, KC .

CIRCULATION RESEARCH, 2006, 98 (03) :351-360

[7] GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation [J].

Xu, J ;

Kimball, TR ;

Lorenz, JN ;

Brown, DA ;

Bauskin, AR ;

Klevitsky, R ;

Hewett, TE ;

Breit, SN ;

Molkentin, JD .

CIRCULATION RESEARCH, 2006, 98 (03) :342-350

[8]

GDF15, a Cardioprotective TGF-β Superfamily Protein[J] . Tetsuro Ago,Junichi Sadoshima.Circulation Research . 2006 (3)

[9] Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure [J].

Wang, J ;

Xu, N ;

Feng, XH ;

Hou, N ;

Zhang, JS ;

Cheng, X ;

Chen, YG ;

Zhang, YY ;

Yang, X .

CIRCULATION RESEARCH, 2005, 97 (08) :821-828

[10]

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study[J] . David A Brown,Samuel N Breit,Julie Buring,W Douglas Fairlie,Asne R Bauskin,Tao Liu,Paul M Ridker.The Lancet . 2002 (9324)

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