凋亡与缺血性神经元损伤

被引：13

作者：

刘士民

机构：

[1] 北京协和医院神经科

来源：

国外医学(脑血管疾病分册) | 1997年 / 02期

关键词：

细胞凋亡; 全脑缺血; 局灶性脑缺血; 再灌注;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

细胞凋亡是不同于坏死的一种细胞死亡形式,现已发现它与多种病理情况有关。文章介绍了国外近几年关于神经元在缺血环境下的凋亡相关基因和蛋白表达、细胞凋亡出现的形式和意义以及可能的机制方面的研究进展。

引用

页码：70 / 74

页数：5

共 10 条

[1] DIFFERENCES IN DNA FRAGMENTATION FOLLOWING TRANSIENT CEREBRAL OR DECAPITATION ISCHEMIA IN RATS [J].

MACMANUS, JP ;

HILL, IE ;

PRESTON, E ;

RASQUINHA, I ;

WALKER, T ;

BUCHAN, AM .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (05) :728-737

[2]

Temporal pattern of internucleosomal DNA fragmentation in the striatum and hippocampus after transient forebrain ischemia[J] . Bruce T. Volpe,Thomas C. Wessel,Bhaskar Mukherjee,Howard J. Federoff.Neuroscience Letters . 1995 (2)

[3] DETECTION OF DNA-DAMAGE INDUCED BY APOPTOSIS IN THE RAT-BRAIN FOLLOWING INCOMPLETE ISCHEMIA [J].

ISLAM, N ;

AFTABUDDIN, M ;

MORIWAKI, A ;

HORI, Y .

NEUROSCIENCE LETTERS, 1995, 188 (03) :159-162

[4]

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death[J] . Laura J.S Greenlund,Thomas L Deckwerth,Eugene M Johnson.Neuron . 1995 (2)

[5] TEMPORAL PROFILE OF IN-SITU DNA FRAGMENTATION AFTER TRANSIENT MIDDLE CEREBRAL-ARTERY OCCLUSION IN THE RAT [J].

LI, Y ;

CHOPP, M ;

JIANG, N ;

YAO, F ;

ZALOGA, C .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (03) :389-397

[6]

p53-Immunoreactive Protein and p53 mRNA Expression After Transient Middle Cerebral Artery Occlusion in Rats[J] . Yi Li,Michael Chopp,Zheng G. Zhang,Cecylia Zaloga,Loreen Niewenhuis,Subhash Gautam.Stroke . 1994 (4)

[7] EVIDENCE SUPPORTING A ROLE FOR PROGRAMMED CELL-DEATH IN FOCAL CEREBRAL-ISCHEMIA IN RATS [J].

LINNIK, MD ;

ZOBRIST, RH ;

HATFIELD, MD .

STROKE, 1993, 24 (12) :2002-2008

[8] NITRIC-OXIDE MEASURED BY A PORPHYRINIC MICROSENSOR IN RAT-BRAIN AFTER TRANSIENT MIDDLE CEREBRAL-ARTERY OCCLUSION [J].

MALINSKI, T ;

BAILEY, F ;

ZHANG, ZG ;

CHOPP, M .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1993, 13 (03) :355-358

[9]

Ultrastructural changes in the hippocampal CA1 region following transient cerebral ischemia: evidence against programmed cell death[J] . Jayant Deshpande,Kerstin Bergstedt,Thomas Lindén,Hannu Kalimo,Tadeusz Wieloch.Experimental Brain Research . 1992 (1)

[10]

Expression of c-fos and c-jun family genes after focal cerebral ischemia .2 An G,Lin T N,Liu J S,et al. Annals of Neurology . 1993

← 1 →