线粒体损伤与神经元缺血死亡

被引：12

作者：

许康

张苏明

机构：

[1] 华中科技大学同济医学院附属同济医院神经内科

[2] 华中科技大学同济医学院附属同济医院神经内科武汉

[3] 武汉

来源：

国外医学脑血管疾病分册 | 2002年 / 06期

关键词：

线粒体; 神经元; 缺血; 坏死; 凋亡;

D O I：

暂无

中图分类号：

R741 [神经病学];

学科分类号：

1002 ;

摘要：

神经元缺血电灌注时由于线粒体损伤,能量代谢衰竭,导致神经元因能量耗竭而死亡。另一方面,线粒体又是细胞凋亡调控网络中最重要的一种细胞器,凋亡调控过程中的一些重要因子,如细胞色素c、Bcl-2家族、caspase前体等都可定位于线粒体,线粒体损伤导致细胞色素c释放和caspase前体释放与激活,从而介导细胞凋亡。因此,线粒体损伤与神经元缺血性死亡有着极其密切的关系。

引用

页码：461 / 464

页数：4

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