PLATINUM COMPLEXES OF SUBSTITUTED ETHYLENEDIAMINES AND THEIR ANTI-TUMOUR ACTIVITY

被引：32

作者：

BEAUMONT, KP

MCAULIFFE, CA

CLEARE, MJ

机构：

[1] UNIV MANCHESTER, INST SCI & TECHNOL, DEPT CHEM, MANCHESTER M60 1QD, LANCASHIRE, ENGLAND

[2] JOHNSON MATTHEY & CO LTD, MANCHESTER, ENGLAND

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1976年 / 14卷 / 1-2期

关键词：

D O I：

10.1016/0009-2797(76)90035-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A large number of substituted ethylenediamine complexes of Pt(II) and Pt(IV) were prepared and characterized, and their antitumor activity was tested against mouse sarcoma 180, leukemia L1210 and ADJ/PC6A plasma cell tumors. These complexes are less active than simpler amine analogs, though several complexes show activity against all of the screens. Difference in activity of Pt(II) and Pt(IV) analogs cast doubt on the in vivo reduction theory hitherto used to describe the action of Pt(IV) complexes.

引用

页码：179 / 193

页数：15

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