DESIGN, SYNTHESIS AND ANTITHROMBIN ACTIVITY FOR CONFORMATIONALLY RESTRICTED ANALOGS OF PEPTIDE ANTICOAGULANTS BASED ON THE C-TERMINAL REGION OF THE LEECH PEPTIDE, HIRUDIN

被引：18

作者：

KRSTENANSKY, JL

OWEN, TJ

YATES, MT

MAO, SJT

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1988年 / 957卷 / 01期

关键词：

D O I：

10.1016/0167-4838(88)90156-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：53 / 59

页数：7

共 10 条

[1]

Chou P Y, 1978, Adv Enzymol Relat Areas Mol Biol, V47, P45

[2] THE CONFORMATIONS OF HIRUDIN IN SOLUTION - A STUDY USING NUCLEAR-MAGNETIC-RESONANCE, DISTANCE GEOMETRY AND RESTRAINED MOLECULAR-DYNAMICS [J].

CLORE, GM ;

SUKUMARAN, DK ;

NILGES, M ;

ZARBOCK, J ;

GRONENBORN, AM .

EMBO JOURNAL, 1987, 6 (02) :529-537

[3] THE HYDROPHOBIC MOMENT DETECTS PERIODICITY IN PROTEIN HYDROPHOBICITY [J].

EISENBERG, D ;

WEISS, RM ;

TERWILLIGER, TC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (01) :140-144

[4] ANTITHROMBIN PROPERTIES OF C-TERMINUS OF HIRUDIN USING SYNTHETIC UNSULFATED N-ALPHA-ACETYL-HIRUDIN45-65 [J].

KRSTENANSKY, JL ;

MAO, SJT .

FEBS LETTERS, 1987, 211 (01) :10-16

[5] ANTICOAGULANT PEPTIDES - NATURE OF THE INTERACTION OF THE C-TERMINAL REGION OF HIRUDIN WITH A NONCATALYTIC BINDING-SITE ON THROMBIN [J].

KRSTENANSKY, JL ;

OWEN, TJ ;

YATES, MT ;

MAO, SJT .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) :1688-1691

[6]

KRSTENANSKY JL, 1988, IN PRESS THROM RES

[7]

KRSTENANSKY JL, 1987, PEPTIDES CHEM BIOL, P447

[8] N-TERMINAL REQUIREMENTS OF SMALL PEPTIDE ANTICOAGULANTS BASED ON HIRUDIN54-65 [J].

OWEN, TJ ;

KRSTENANSKY, JL ;

YATES, MT ;

MAO, SJT .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (05) :1009-1011

[9]

STEWART JM, 1984, SOLID PHASE PEPTIDE, P116

[10]

SUKUMARAN D K, 1987, Biochemistry, V26, P333, DOI 10.1021/bi00376a001

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