COMMON VIRULENCE FACTORS FOR BACTERIAL PATHOGENICITY IN PLANTS AND ANIMALS

被引：1019

作者：

RAHME, LG

STEVENS, EJ

WOLFORT, SF

SHAO, J

TOMPKINS, RG

AUSUBEL, FM

机构：

[1] HARVARD UNIV, SCH MED, DEPT GENET, BOSTON, MA 02114 USA

[2] MASSACHUSETTS GEN HOSP, DEPT MOLEC BIOL, BOSTON, MA 02114 USA

[3] MASSACHUSETTS GEN HOSP, SHRINERS BURNS INST, BOSTON, MA 02114 USA

[4] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT SURG, BOSTON, MA 02114 USA

来源：

SCIENCE | 1995年 / 268卷 / 5219期

关键词：

D O I：

10.1126/science.7604262

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidqosis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.

引用

页码：1899 / 1902

页数：4

共 33 条

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[2]

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[3]

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