TRANSGENIC MOUSE MODELS OF LIPOPROTEIN METABOLISM AND ATHEROSCLEROSIS

被引：118

作者：

BRESLOW, JL

机构：

[1] Biochemical Genetics/Metabolism Lab., Rockefeller University, New York, NY 10021-6399

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 18期

关键词：

APOLIPOPROTEIN; DIET; CHOLESTEROL;

D O I：

10.1073/pnas.90.18.8314

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipoprotein transport genes have either been added to the germ line of mice by transgenic techniques or knocked out by homologous recombination in embryonic stem cells. The resultant over- or underexpression of these genes has resulted in new insights about how these genes function in the body and their role in lipoprotein metabolism. Either singly or in combination, these genetic modifications can be used to engineer the mouse to make it a better model for human lipoprotein disorders and atherosclerosis.

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收藏

页码：8314 / 8318

页数：5

相关论文

共 38 条

[1] MECHANISM OF HYPERTRIGLYCERIDEMIA IN HUMAN APOLIPOPROTEIN-(APO)-CIII TRANSGENIC MICE - DIMINISHED VERY LOW-DENSITY-LIPOPROTEIN FRACTIONAL CATABOLIC RATE ASSOCIATED WITH INCREASED APO-CIII AND REDUCED APO-E ON THE PARTICLES [J].

AALTOSETALA, K ;

FISHER, EA ;

CHEN, XL ;

CHAJEKSHAUL, T ;

HAYEK, T ;

ZECHNER, R ;

WALSH, A ;

RAMAKRISHNAN, R ;

GINSBERG, HN ;

BRESLOW, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (05) :1889-1900

[2]

AGELLON LB, 1991, J BIOL CHEM, V266, P10796

[3] LIPOPROTEIN TRANSPORT GENE ABNORMALITIES UNDERLYING CORONARY HEART-DISEASE SUSCEPTIBILITY [J].

BRESLOW, JL .

ANNUAL REVIEW OF MEDICINE, 1991, 42 :357-371

[4] EXPRESSION OF THE HUMAN APOLIPOPROTEIN-A-I GENE IN TRANSGENIC MICE ALTERS HIGH-DENSITY-LIPOPROTEIN (HDL) PARTICLE-SIZE DISTRIBUTION AND DIMINISHES SELECTIVE UPTAKE OF HDL CHOLESTERYL ESTERS [J].

CHAJEKSHAUL, T ;

HAYEK, T ;

WALSH, A ;

BRESLOW, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (15) :6731-6735

[5]

CHIESA G, 1992, J BIOL CHEM, V267, P24369

[6] AN APOLIPOPROTEIN CIII HAPLOTYPE PROTECTIVE AGAINST HYPERTRIGLYCERIDEMIA IS SPECIFIED BY PROMOTER AND 3' UNTRANSLATED REGION POLYMORPHISMS [J].

DAMMERMAN, M ;

SANDKUIJL, LA ;

HALAAS, JL ;

CHUNG, W ;

BRESLOW, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4562-4566

[7] PROBUCOL DECREASES APOLIPOPROTEIN A-I TRANSPORT RATE AND INCREASES HIGH-DENSITY-LIPOPROTEIN CHOLESTERYL ESTER FRACTIONAL CATABOLIC RATE IN CONTROL AND HUMAN APOLIPOPROTEIN A-I TRANSGENIC MICE [J].

HAYEK, T ;

CHAJEKSHAUL, T ;

WALSH, A ;

AZROLAN, N ;

BRESLOW, JL .

ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (05) :1295-1302

[8] DIETARY-FAT INCREASES HIGH-DENSITY-LIPOPROTEIN (HDL) LEVELS BOTH BY INCREASING THE TRANSPORT RATES AND DECREASING THE FRACTIONAL CATABOLIC RATES OF HDL CHOLESTEROL ESTER AND APOLIPOPROTEIN (APO) A-I - PRESENTATION OF A NEW ANIMAL-MODEL AND MECHANISTIC STUDIES IN HUMAN APO A-I TRANSGENIC AND CONTROL MICE [J].

HAYEK, T ;

ITO, Y ;

AZROLAN, N ;

VERDERY, RB ;

AALTOSETALA, K ;

WALSH, A ;

BRESLOW, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) :1665-1671

[9] AN INTERACTION BETWEEN THE HUMAN CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) AND APOLIPOPROTEIN-A-I GENES IN TRANSGENIC MICE RESULTS IN A PROFOUND CETP-MEDIATED DEPRESSION OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL LEVELS [J].

HAYEK, T ;

CHAJEKSHAUL, T ;

WALSH, A ;

AGELLON, LB ;

MOULIN, P ;

TALL, AR ;

BRESLOW, JL .

JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (02) :505-510

[10] LDL RECEPTOR-RELATED PROTEIN INTERNALIZES AND DEGRADES UPA-PAI-1 COMPLEXES AND IS ESSENTIAL FOR EMBRYO IMPLANTATION [J].

HERZ, J ;

CLOUTHIER, DE ;

HAMMER, RE .

CELL, 1992, 71 (03) :411-421

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