PRODUCTION OF ROSMARINIC ACID FROM PERFUSION CULTURE OF ANCHUSA-OFFICINALIS IN A MEMBRANE-AERATED BIOREACTOR

被引：1

作者：

WEI, WS

HUMPHREY, AE

机构：

[1] LEHIGH UNIV,DEPT CHEM ENGN,BETHLEHEM,PA 18015

[2] UNIV HAWAII,DEPT AGR ENGN,HONOLULU,HI 96822

来源：

BIOTECHNOLOGY LETTERS | 1991年 / 13卷 / 12期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this study, a perfusion fermentation of Anchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was used to provide oxygen. A two-stage culture was successfully conducted in this reactor without filter fouling. In a 17 day fermentation, a cell density of 26 g dw/l and a rosmarinic acid productivity of 94 mg/1-day were achieved. This productivity is three times that obtained in a batch culture.

引用

页码：889 / 892

页数：4